Reflex inhibition of renal sympathetic nerve activity during myocardial ischemia mediated by left ventricular receptors with vagal afferents in dogs.
Reflex inhibition of renal sympathetic nerve activity during myocardial ischemia mediated by left ventricular receptors with vagal afferents in dogs.
复制标题
狗心肌缺血期间肾交感神经活动的反射抑制由左心室受体与迷走神经传入介导。
DOI：
10.1172/jci109315
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
F. Abboud
中科院分区：
文献类型：
--
作者：
M. Thames;F. Abboud
这项研究的主要目的是确定冠状动脉闭塞期间心脏受体的激活是否可以抑制传出的肾交感神经活动。在9只氯醛糖麻醉犬(n=3或n=6)行压力感受器阻断后，冠状动脉前降支(LAD)阻断后平均动脉压(-9.8±-5.1 mm Hg，NS)略有下降(P<0.05)，肾神经活动显著增加(24.0±-4.1%)。在这些犬中，冠状动脉回旋支(CX)阻断导致更大的低血压(-18.4+/-4.0 mm Hg)，但肾神经活动没有变化(1.1+/-9%)。左房内压在LAD和CX结扎期间的变化无差异。在7只失去颈动脉窦神经的狗中，冠状动脉闭塞导致动脉压和肾神经活动的下降，而在Cx闭塞期间，这两种下降的幅度一直更大。6只犬去窦主动脉传入后对冠脉阻塞的反应与仅去神经支配颈动脉窦的反应相似。在所有实验中，迷走神经切断术消除了Cx阻断时血压反应的差异和肾交感神经活动的下降。迷走神经切断术也消除了颈动脉或窦主动脉失神经的犬在LAD阻断期间神经活动的下降。这些数据表明，Cx阻断和LAD阻断(程度较轻)可引起由迷走神经传入的左心室受体介导的肾交感神经活动的反射性收缩。尽管有低血压和正常工作的窦-主动脉压力感受器的存在，但在CX阻断期间肾神经活动仍发生反射性收缩。
The major goal of this investigation was to determine if activation of cardiac receptors during coronary artery occlusion could inhibit efferent renal sympathetic nerve activity. In nine chloralose anesthetized dogs with only carotid (n = 3) or with sinoaortic (n = 6) baroreceptors operative, anterior descending coronary artery (LAD) occlusion resulted in a small decrease in mean arterial pressure (-9.8+/-5.1 mm Hg, NS) and in a significant (P < 0.05) increase in renal nerve activity (24.0+/-4.1%). In these dogs, circumflex coronary artery (Cx) occlusion resulted in greater hypotension (-18.4+/-4.0 mm Hg), and yet no change (1.1+/-9%) in renal nerve activity was noted. Changes in left atrial pressure during LAD and Cx occlusion were not different. In seven dogs with carotid sinus denervation, coronary occlusions resulted in decreases both in arterial pressure and in renal nerve activity which were consistently greater during Cx occlusion. The responses to coronary occlusion in six dogs after sinoaortic deafferentation were similar to those observed with only carotid sinuses denervated. In all experiments, vagotomy abolished the difference in the blood pressure responses and the decreases in renal sympathetic nerve activity during Cx occlusion. Vagotomy also abolished the decrease in nerve activity during LAD occlusion in dogs with carotid or sinoaortic denervation. These data show that Cx occlusion and, to a lesser degree, LAD occlusion resulted in reflex withdrawal of renal sympathetic nerve activity mediated by left ventricular receptors with vagal afferents. The reflex withdrawal of renal nerve activity during Cx occlusion occurred in spite of hypotension and the presence of functioning sinoaortic baroreceptors.