Unexpected high prevalence of IgG-antibodies to hepatitis E virus in Swedish pig farmers and controls
Unexpected high prevalence of IgG-antibodies to hepatitis E virus in Swedish pig farmers and controls
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DOI：
10.1080/00365540500321470
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Weiland, O
中科院分区：
文献类型：
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作者：
Olsen, BR;Axelsson-Olsson, D;Weiland, O
戊型肝炎病毒 (HEV) 感染是发展中国家大规模水传播疾病暴发的原因。发达国家的散发病例主要是通过来自流行地区的移民和旅行者输入的。戊型肝炎病毒被认为是一种人畜共患感染，猪可能是该疾病的重要宿主，并且已鉴定出特定猪型戊型肝炎病毒株也可以感染人类。本研究的目的是分析瑞典养猪户是否比其他职业的人更容易接触 HEV。共有 115 名 40-60 岁的男性养猪户和 108 名年龄和地理匹配的对照受试者接受了 IgG 抗 HEV 抗体检测。养猪户 (13.0%) 和对照组 (9.3%) 之间的抗 HEV 感染率没有统计学差异。养猪户和对照人群中抗 HEV 抗体的患病率高于之前报道的欧洲其他人群 (< 1-9%)。需要进一步研究来阐明本土 HEV 的感染途径以及瑞典是否发生与猪相关的 HEV 菌株的亚临床感染。
Hepatitis E virus (HEV) infections are responsible for large waterborne outbreaks in developing countries. Sporadic cases in the developed world are mainly imported via immigrants and travellers from endemic areas. HEV has been suggested to be a zoonotic infection where pigs may be an important reservoir for the disease and specific swine strains of HEV have been identified which can infect also humans. The aim of this study was to analyse if Swedish pig farmers are more exposed to HEV than persons with other occupations. A total of 115 male pig farmers aged 40-60 y and 108 age- and geographically-matched control subjects were tested for IgG anti-HEV antibodies. No statistical difference in anti-HEV prevalence was noted between pig farmers (13.0%) and control subjects (9.3%). The prevalence of anti-HEV antibodies in the pig farmers and controls was higher than that previously reported among other populations in Europe (< 1-9%). Further studies are needed to elucidate the routes for infection of indigenous HEV and if sub-clinical infections with pig associated HEV strains occur in Sweden.