Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women
Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women
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DOI：
10.1038/sj.ejcn.1602494
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发表时间：
2007-01-01
影响因子：
4.7
通讯作者：
Kaaks, R.
中科院分区：
文献类型：
--
作者：
Norat, T.;Dossus, L.;Kaaks, R.
目的：本研究的目的是探讨女性饮食与血清胰岛素样生长因子-I (IGF-I) 和 IGF 结合蛋白-3 的关系。设计：横断面研究。背景和受试者：受试者为 2109 名女性，她们是欧洲癌症与营养前瞻性调查中乳腺癌病例对照研究的对照受试者。对照受试者是从风险组中随机选择的，这些风险组由在诊断指示病例时存活且未患癌症（非黑色素瘤皮肤癌除外）的女性队列成员组成。匹配标准是入组时的年龄、随访时间、采血当天的时间和研究中心。饮食通过经过验证的问卷进行测量。通过酶联免疫吸附测定法测量血清激素浓度。在调整能量摄入、年龄、体重指数、吸烟、体力活动、中心和实验室批次的模型中，通过线性回归探讨血清 IGF-I、IGFBP-3 与营养素和食物摄入之间的关系。 结果：血清 IGF-I 水平与蛋白质摄入量呈正相关（P 趋势 < 0.001），但与能量、脂肪或碳水化合物摄入量无关。与牛奶 (P-趋势 = 0.007)、钙 (P-趋势 < 0.001)、镁 (P-趋势 = 0.003)、磷 (P-趋势 < 0.001)、钾 (P-趋势 = 0.002)、维生素 B6 (P-趋势 = 0.03)、维生素 B2 (P-趋势 = 0.001) 和与蔬菜 (P-趋势 = 0.02) 和 β-胡萝卜素 (P-趋势 = 0.02) 呈反比关系。 IGFBP-3 与本研究中的大多数营养素和食物无关。结论：在该人群中，循环 IGF-I 与蛋白质和矿物质以及牛奶和奶酪的摄入量有一定关系，而 IGFBP-3 似乎与饮食无关。
Objective: The aim of this study was to examine the relationship of diet with serum insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in women.Design: Cross-sectional study.Setting and subjects: The population are 2109 women who were control subjects in a case-control study of breast cancer nested in the European Prospective Investigation into Cancer and Nutrition. Control subjects were randomly chosen among risk sets consisting of female cohort members alive and free of cancer (except non-melanoma skin cancer) at the time of diagnosis of the index case. Matching criteria were age at enrolment, follow-up time, time of the day of blood collection and study centre. Diet was measured through validated questionnaires. Serum hormone concentrations were measured by enzyme-linked immunosorbent assays. The relationship between serum IGF-I, IGFBP-3, and intake of nutrients and foods was explored by linear regression in models adjusted for energy intake, age, body mass index, smoking, physical activity, centre and laboratory batch.Results: Serum IGF-I levels were positively related to protein intake (P-trend < 0.001), but not related to energy, fat or carbohydrate intake. Positive relationships were observed with the intake of milk (P-trend = 0.007), calcium (P-trend < 0.001), magnesium (P-trend = 0.003), phosphorus (P-trend < 0.001), potassium (P-trend = 0.002), vitamin B6 (P-trend = 0.03), vitamin B2 (P-trend = 0.001) and inverse relationships with vegetables (P-trend = 0.02) and beta-carotene (P-trend = 0.02). IGFBP-3 was not related with most of the nutrients and foods in this study.Conclusions: In this population, circulating IGF-I is modestly related with the intake of protein and minerals, and with milk and cheese, while IGFBP-3 does not appear to be related with diet.