Ultraviolet radiation and the development of non-melanoma and melanoma skin cancer: clinical and experimental evidence.
Ultraviolet radiation and the development of non-melanoma and melanoma skin cancer: clinical and experimental evidence.
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紫外线辐射与非黑色素瘤和黑色素瘤皮肤癌的发展：临床和实验证据。
DOI：
10.1159/000210987
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Pathak,MA
中科院分区：
文献类型：
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作者：
Pathak,MA
临床和实验证据解释和支持的作用，紫外线辐射作为一个因果因素的诱导和促进非黑色素瘤和恶性黑色素瘤皮肤癌。虽然有很好的动物实验数据和人类流行病学证据支持UVR（UVB和UVA辐射）与基底细胞癌和鳞状细胞癌之间的因果关系，但建立黑色素瘤和日光暴露之间直接因果关系的数据似乎很复杂。然而，他们确实表明了阳光在黑色素瘤的病因中起着明确的促进作用。使用无毛色素小鼠品系（Skh-hr 2），实验开始检查UVR在黑色素瘤诱导中的作用。单次应用DMBA作为引发剂，随后每周三次暴露于UVB（290-320 nm）或UVA（320-400 nm）或UVA和UVB的组合暴露导致形成蓝痣样病变。重复紫外线照射超过30周导致黑色素瘤（38%）的发展，以及淋巴瘤和鳞状细胞癌，只有在那些用DMBA预处理的小鼠和发展痣。接受UVB、UVA或UVB + UVA联合治疗而不进行DMBA预处理的小鼠发生乳头状瘤和鳞状细胞癌，但没有黑色素瘤。这些研究表明，在UVR（UVB+ UVA）可以作为促进剂并加速恶性黑色素瘤以及淋巴瘤的发展之前，一些起始事件对于黑色素细胞转化为蓝痣样病变是必不可少的。
Clinical and experimental evidence explaining and supporting the role of UV radiation as a causal factor for the induction and promotion of nonmelanoma and malignant melanoma skin cancer are presented. While there is excellent animal experimental data and human epidemiologic evidence supporting the causal relationship of UVR (UVB, as well as UVA radiation) for basal and squamous cell carcinomas, the data establishing a direct causal relationship between melanoma and exposure to sunlight appear to be complex. They do, however, suggest a definite promotional role of sunlight in the causation of melanoma. Using a hairless pigmented mouse strain (Skh-hr2), experiments were initiated to examine the role of UVR in the induction of melanoma. A single application of DMBA as an initiator and subsequent thrice-weekly exposures to either UVB (290–320 nm) or UVA (320–400 nm) or the combined exposures of UVA and UVB resulted in the formation of blue nevus-like lesions. Repeated UVR exposures for over 30 weeks resulted in the development of melanoma (38%), as well as lymphoma and squamous cell carcinoma only in those mice that were pretreated with DMBA and had developed nevi. Mice receiving UVB, UVA, or the combination treatments of UVB plus UVA without DMBA pretreatment developed papillomas and squamous cell carcinoma but no melanoma. These studies indicate that some initiation event is essential to transform melanocytes to blue nevus-like lesions before UVR (UVB+ UVA) can act as a promoter and accelerate the development of malignant melanoma, as well as lymphoma.