The Role of the Immune System Beyond the Fight Against Infection
The Role of the Immune System Beyond the Fight Against Infection
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DOI：
10.1007/978-3-319-57613-8_1
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Sattler, Susanne
中科院分区：
文献类型：
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作者：
Sattler, Susanne
免疫系统在世纪前被确定为传染病期间的保护因素。目前的定义和教科书信息仍然在很大程度上受到这些早期观察的影响，免疫系统通常被视为一种防御机制。然而，宿主防御只是免疫系统维持组织稳态和系统完整性的整体功能的一种表现。事实上，免疫系统是基本生理过程（如发育、生殖和伤口愈合）的组成部分，并且免疫系统与其他身体系统（如代谢、中枢神经系统和心血管系统）之间的密切串扰是显而易见的。越来越多的研究和医学专业人员开始认识到免疫系统在各自领域的意义，本章简要介绍了我们对免疫系统的理解是如何从防御系统演变为维持组织完整性的总体监视机制的。目前的观点对经典的免疫细胞和因子的非防御功能也将进行讨论。
The immune system was identified as a protective factor during infectious diseases over a century ago. Current definitions and textbook information are still largely influenced by these early observations, and the immune system is commonly presented as a defence machinery. However, host defence is only one manifestation of the immune system’s overall function in the maintenance of tissue homeostasis and system integrity. In fact, the immune system is integral part of fundamental physiological processes such as development, reproduction and wound healing, and a close crosstalk between the immune system and other body systems such as metabolism, the central nervous system and the cardiovascular system is evident. Research and medical professionals in an expanding range of areas start to recognise the implications of the immune system in their respective fields.This chapter provides a brief historical perspective on how our understanding of the immune system has evolved from a defence system to an overarching surveillance machinery to maintain tissue integrity. Current perspectives on the non-defence functions of classical immune cells and factors will also be discussed.