Early forms of terminal degeneration in the spinal trigeminal nucleus following rhizotomy
Early forms of terminal degeneration in the spinal trigeminal nucleus following rhizotomy
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脊神经根切断术后三叉神经脊椎终末变性的早期形式
DOI：
10.1007/bf01474720
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
L. Westrum
中科院分区：
文献类型：
--
作者：
L. Westrum
本研究对成年猫三叉神经脊束核内隔部在三叉神经后根切断术后早期和连续存活时间进行了电子显微镜观察。结果表明，轴突终末发生了几种不同形式的退行性改变，其中一些形式可能被解释为某些终末退变序列中的阶段。突触小泡耗竭和线粒体改变可能是某些终末最早的变化，但在非常早期的存活时间也出现了完全不同的形式，这表明可能有其他过程参与。后期存活者的电子致密形式的末端退化被认为是由至少四种可能的类型或类别的早期改变中的任何一种引起的，这些改变基于囊泡和神经丝的存在或不存在以及线粒体的改变。电子荧光形式可能会随着时间的推移而演变为致密类型，但可能只占后来致密形式的一部分。所有类型的神经胶质细胞或反应性胶质细胞，以及可能的第三种胶质细胞，都比先前报道的更早参与突触后部位的早期和快速吞噬和剥离。这项研究也证实了先前在同一区域进行的与时间相关的退化模式的研究，并对这种模式提供了解释。
SummaryPars interpolaris of the spinal trigeminal nucleus in adult cats has been studied with the electron microscope at several early and consecutive postoperative survival times following retrogasserian rhizotomy. The results show that several different forms of degenerative changes occur in the axon terminals and some of these forms may be interpreted as stages in certain sequences of terminal degeneration.Synaptic vesicle depletion and mitochondrial alterations are probably the earliest changes in some terminals, but the occurrence of completely different forms also at very early survival times suggest that other processes may be involved. Electron-dense forms of terminal degeneration of later survivals are suggested as arising from any of at least four possible types or classes of earlier alterations based upon presence or absence of vesicles and neurofilaments and on the mitochondrial changes. Electron-lucent forms probably progress to dense types with time but may account for only a proportion of the later dense forms.All types of neuroglia, or reactive glia, and a possible ‘third glia’ are involved in early and rapid phagocytosis and denudation of post-synaptic sites at times earlier than previously reported.The study also confirms a previous study of a time-related degeneration pattern in the same area and offers an explanation for this pattern.