The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
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DOI：
10.1177/1179064418761639
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Sims-Mourtada J
中科院分区：
文献类型：
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作者：
Arnold KM;Flynn NJ;Raben A;Romak L;Yu Y;Dicker AP;Mourtada F;Sims-Mourtada J
除了在肿瘤和间质细胞中诱导致命的DNA损伤外，辐射还可以改变肿瘤细胞与其微环境的相互作用。最近在计划和提供体外放射治疗方面的技术进步使得能够以更高的精度提供更大的每部分剂量(低分割)，同时以更高的精度将正常组织的剂量降至最低。放射治疗对肿瘤微环境的影响因剂量和分割程序的不同而不同。在这篇综述中，我们总结了常规和低分割放射治疗方案对免疫系统和肿瘤间质的影响。我们讨论了这些相互作用如何结合靶向治疗提供治疗益处。了解辐射剂量和分割的不同影响对选择联合疗法具有重要意义。
In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the interactions of tumor cells with their microenvironment. Recent technological advances in planning and delivery of external beam radiotherapy have allowed delivery of larger doses per fraction (hypofractionation) while minimizing dose to normal tissues with higher precision. The effects of radiation on the tumor microenvironment vary with dose and fractionation schedule. In this review, we summarize the effects of conventional and hypofractionated radiation regimens on the immune system and tumor stroma. We discuss how these interactions may provide therapeutic benefit in combination with targeted therapies. Understanding the differential effects of radiation dose and fractionation can have implications for choice of combination therapies.