REACTIONS TO SKIN ALLOGRAFTS IN THE HORN SHARK, HETERODONTIS FRANCISCI
REACTIONS TO SKIN ALLOGRAFTS IN THE HORN SHARK, HETERODONTIS FRANCISCI
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角鲨异体皮肤移植的反应
DOI：
10.1097/00007890-197012000-00012
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发表时间：
1970
期刊：
影响因子：
6.2
通讯作者：
W. Hildemann
中科院分区：
文献类型：
--
作者：
M. Borysenko;W. Hildemann
在22±1℃的温度下研究了角鲨的组织排斥反应能力。这种原始的弹性肌支需要几次连续的同种异体皮肤移植才能达到剧烈的反应水平。连续四组同种异体移植物的中位存活时间分别为41.1、16.7、9.3和7.4天。第一次和第二次同种异体移植排斥反应的特征主要是缓慢的黑素载体细胞破坏和轻微的炎症。另一方面，第三和第四组同种异体移植排斥反应通常类似于“白色移植反应”，表现为严重出血、增生和愈合不良。这种从慢性到急性反应的进展与弱组织相容性系统的基本特征相似，特别是小鼠的非H-2系统。
The tissue rejection capacity of the horn shark, Heterodontis francisci, was studied at 22 ± 1 C. This primitive elasmobranch requires several successive skin allograft challenges to attain an acute level of reactivity. Four successive sets of allografts showed median survival times of 41.1, 16.7, 9.3, and 7.4 days, respectively. First- and second-set allograft rejections were characterized mainly by slow melanophore cell destruction and mild inflammation. On the other hand, third- and fourth-set allograft rejections often resembled “white graft reactions,‘’ showing severe hemorrhage, hyperplasia, and poor healing. Such a progression from chronic to acute reactivity parallels the basic characteristics of weak histocompatibility systems, particularly the non-H-2 system of the mouse.