Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora
Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora
复制标题
Dysoxylum gotadhora 叶和枝中的抗炎萜类化合物
DOI：
10.1021/np5010196
复制
发表时间：
2015-05-01
影响因子：
5.1
通讯作者：
Gao, Kun
中科院分区：
文献类型：
--
作者：
Jiang, Kan;Chen, Lu-Lin;Gao, Kun
从桃木的叶和枝中分离得到9个新的萜类化合物（1- 3,5 -10），包括3个环烷三萜（1-3）和6个异吡玛烷二萜（5-10），以及6个已知的萜类化合物（4,11 -15）。化合物1是一类稀有的天然21,24-环氧环烷型三萜，化合物2和3是21,25-环氧环烷型三萜的首个实例。化合物1、2、4、8和15对脂多糖诱导的RAW 264.7细胞一氧化氮产生有明显的抑制作用，IC50值分别为25.5、41.5、27.4、14.5和45.2 μ M。
Nine new terpenoids (1-3, 5-10), including three cyclolanostane triterpenoids (1-3) and six isopimarane diterpenoids (5-10), along with six known terpenoids (4, 11-15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 mu M, respectively.