Blink reflex habituation in migraine and chronic tension-type headache
Blink reflex habituation in migraine and chronic tension-type headache
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DOI：
10.1007/s10072-017-2885-x
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发表时间：
2017-06-01
影响因子：
3.3
通讯作者：
Papadimitriou, Alexandros
中科院分区：
文献类型：
--
作者：
Avramidis, Theodoros;Bougea, Anastasia;Papadimitriou, Alexandros
对55例慢性紧张性头痛患者、55例偏头痛患者和55例无头痛患者的R1和R2眨眼反射潜伏期进行盲测。应用标准电刺激眶上神经，记录同侧眼轮匝肌的反应。三组之间R1或R2潜伏期无差异。在偏头痛发作期间，我们观察到R2振幅和面积有统计学意义的减少。本研究的主要发现是，与紧张性头痛和对照组相比，偏头痛患者在不同的刺激间隔中引发了晚R2”反应。这可能被认为是习惯化机制的一个迹象，尽管需要进一步的研究来证实这些发现并建立神经生理学基础。这项研究表明，眨眼反射研究可以作为一种常规的非回避和廉价的方法来评估头痛患者。
R1 and R2 blink reflex latencies were investigated blind in 55 patients with chronic tension-type headache, 55 patients with migraine, and 55 headache-free controls. Standard electrical stimulation of the supraorbital nerve was applied and the response was recorded from the ipsilateral orbicularis oculi muscles. There were no R1 or R2 latency differences between the three groups. During migraine attacks we observed a statistically significant reduction of R2 amplitude and area. The main finding of our study was the elicitation of the late R2" response at different interstimulus intervals in migraine patients compared to the tension-type headache and control groups. This could be considered an indication of habituation mechanism hyperexcitability, although further investigation is needed to confirm these findings and establish the neurophysiologic basis. This study suggests that blink reflex studies can be used routinely as a non-evasive and inexpensive method for the evaluation of headache patients.