Descriptive profile of PIK3CA-mutated colorectal cancer in postmenopausal women.
Descriptive profile of PIK3CA-mutated colorectal cancer in postmenopausal women.
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DOI：
10.1007/s00384-013-1715-8
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发表时间：
2013-12
影响因子：
2.8
通讯作者：
Newcomb PA
中科院分区：
文献类型：
--
作者：
Phipps AI;Makar KW;Newcomb PA
大约10- 30%的结肠直肠癌在磷酸肌醇-3-激酶催化α多肽基因（PIK 3CA）中表现出体细胞突变。我们评估了PIK 3CA突变状态与人口统计学因素、生活方式因素和其他肿瘤特征之间的关系，以及PIK 3CA突变状态与结直肠癌生存率之间的关系。这项基于人群的研究包括1998年至2002年在西华盛顿州诊断为浸润性结直肠癌的绝经后妇女。对参与者进行了采访，并对肿瘤标本进行了外显子9和20热点中的PIK 3CA突变、KRAS外显子2突变、BRAF p.V600E突变和微卫星不稳定性的检测。我们使用考克斯回归来评估PIK 3CA突变状态与疾病特异性生存期和总生存期之间的相关性。按KRAS突变状态进行分层分析。PIK 3CA突变在大约13%的病例中是明显的（N=35）。患有PIK 3CA突变的结直肠癌的女性比患有PIK 3CA野生型疾病的女性更有可能是非白人，患有近端结肠癌和KRAS突变的肿瘤（p<0.05）。在考克斯比例风险回归分析中，患有PIK 3CA突变的女性与野生型结直肠癌的女性相比，总生存期较差，尽管在统计学上不显著（风险比=1.74，95%置信区间0.86-3.50）。PIK 3CA突变状态与生存期之间的这种关联仅在分析仅限于无体细胞KRAS突变的病例时才明显（风险比=2.94，95%置信区间1.12-7.73）。PIK 3CA突变的结直肠癌似乎具有具有临床意义的独特流行病学特征。患有PIK 3CA突变的结直肠癌的女性比患有PIK 3CA野生型疾病的女性预后更差。
Approximately 10–30 % of colorectal cancers exhibit somatic mutations in the phosphoinositide-3-kinase, catalytic, alpha polypeptide gene (PIK3CA). We evaluated the relationship between PIK3CA mutation status and demographic factors, lifestyle factors, and other tumor characteristics and the relationship between PIK3CA mutation status and colorectal cancer survival. The population-based study included postmenopausal women with invasive colorectal cancer diagnosed between 1998 and 2002 in Western Washington State. Participants were interviewed, and tumor specimens were tested for PIK3CA mutations in exons 9 and 20 hotspots, KRAS exon 2 mutations, BRAF p.V600E mutation, and microsatellite instability. We used Cox regression to evaluate the association between PIK3CA mutation status and disease-specific and overall survival. Stratified analyses were conducted by KRAS mutation status. PIK3CA mutations were evident in approximately 13 % of cases (N=35). Women with PIK3CA-mutated colorectal cancer were significantly more likely than those with PIK3CA wild-type disease to be non-white, to have proximal colon cancer, and to have KRAS-mutated tumors (p<0.05). In Cox proportional hazards regression analyses, overall survival was poorer, although not statistically significantly so, for women with PIK3CA-mutated versus wild-type colorectal cancer (hazard ratio=1.74, 95 % confidence interval 0.86–3.50). This association between PIK3CA mutation status and survival was evident only when analyses were restricted to cases without somatic KRAS mutations (hazard ratio=2.94, 95 % confidence interval 1.12–7.73). PIK3CA-mutated colorectal cancer appears to have a distinct epidemiologic profile that is of clinical significance. Women with PIK3CA-mutated colorectal cancer experience a poorer prognosis than those with PIK3CA wild-type disease.
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影响因子：
3.7
作者：
Garrido-Laguna I;Hong DS;Janku F;Nguyen LM;Falchook GS;Fu S;Wheler JJ;Luthra R;Naing A;Wang X;Kurzrock R
通讯作者：
Kurzrock R
影响因子：
4.3
作者：
Samuels, Y;Velculescu, VE
通讯作者：
Velculescu, VE
影响因子：
2.6
作者：
Oliner, Kelly;Juan, Todd;Patterson, Scott D.
通讯作者：
Patterson, Scott D.
影响因子：
6.4
作者：
Whitehall, Vicki L. J.;Rickman, Celestine;Leggett, Barbara A.
通讯作者：
Leggett, Barbara A.
影响因子：
30.8
作者：
Weisenberger, Daniel J.;D Siegmund, Kimberly;Laird, Peter W.
通讯作者：
Laird, Peter W.