Fetal growth retardation as a cause of impaired ovarian development
Fetal growth retardation as a cause of impaired ovarian development
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DOI：
10.1016/s0378-3782(97)00073-x
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发表时间：
1998-04-17
影响因子：
2.5
通讯作者：
Te Velde, ER
中科院分区：
文献类型：
--
作者：
de Bruin, JP;Dorland, M;Te Velde, ER
低出生体重与以后生活中的疾病和障碍有关。有人认为这是由于腹部器官发育受损造成的，特别是在生长迟缓的情况下。除了胎儿的一般营养不良外，优先流向心脏和大脑的血流可能进一步剥夺器官，如肝脏，胰腺和肾脏的营养。因此，这些器官可能无法正常发育。从解剖学上讲，卵巢靠近肾脏，与肾脏相似，卵巢发育很可能会受到子宫内生长迟缓的负面影响。胎盘功能不全，这是一个重要的原因，严重的宫内生长迟缓，被用作模型来研究这一假设。在本研究中，四个不同胎龄的严重生长迟缓胎儿卵巢中原始卵泡的体积百分比与四个年龄匹配的对照进行了比较。结果发现，这些体积百分比在生长迟缓的胎儿显着低于年龄匹配的对照组中观察到的。由此可见，宫内生长迟缓胎儿卵巢发育受损。这些发现进一步表明，由于卵泡过早丢失，出生体重低的女性可能会在以后的生活中遇到生育问题。(C)1998爱思唯尔科学爱尔兰有限公司
Low birthweight has been associated with diseases and disorders later in life. It has been suggested that this is caused by the impaired development of abdominal organs, especially in cases of growth retardation. Besides general malnutrition of the fetus, preferential bloodflow to the heart and brain may further deprive organs, such as liver, pancreas and kidney, of nutrients. As a result these organs may not develop properly. Anatomically, the ovary is situated close to the kidney and it is very likely that, similar to the kidney, ovarian development can be negatively affected by intra-uterine growth retardation. Placental insufficiency, which is an important cause of severe intra-uterine growth retardation, was used as a model to investigate this hypothesis. In the present study, the volume percentages of primordial follicles in the ovaries of four severely growth-retarded fetuses of different gestational ages are compared to those of four age-matched controls. It is found that these volume percentages in growth-retarded fetuses were significantly lower than those observed in the age-matched controls. It can be concluded that ovarian development is impaired in intra-uterine growth-retarded fetuses. These findings further suggest that, as a result of the premature loss of follicles, females with low birthweights may encounter fertility problems later in life. (C) 1998 Elsevier Science Ireland Ltd.