The Prothrombotic State in Rheumatoid Arthritis: An Additive Risk Factor for Adverse Cardiovascular Events
The Prothrombotic State in Rheumatoid Arthritis: An Additive Risk Factor for Adverse Cardiovascular Events
复制标题
DOI：
10.1055/s-0030-1254054
复制
发表时间：
2010-06-01
影响因子：
5.7
通讯作者：
Stroes, Eric S. G.
中科院分区：
文献类型：
--
作者：
Bisoendial, Radjesh J.;Levi, Marcel;Stroes, Eric S. G.
风湿性关节炎（RA）已被公认为增加心血管疾病的发病率和死亡率独立于既定的危险因素。慢性炎症状态是RA的标志，被认为是一种自主风险因素，而先天免疫和适应性免疫的成分被认为有助于急性心血管事件的发生。一些研究表明，RA赋予血栓前状态，其特征在于凝血和纤溶系统异常以及血小板反应性的改变。可以想象，这些研究结果可能是部分工具的RA不良心血管事件的风险增加。旨在减弱炎症性疾病活动和干预炎症介质和血栓形成之间的串扰点的治疗策略可能有助于减少RA患者的心血管疾病负担。
Rheumatoid arthritis (RA) has been recognized to increase cardiovascular morbidity and mortality independent of established risk factors. The chronic inflammatory state, a hallmark of RA, is considered an autonomous risk factor, whereas components of innate and adaptive immunity are believed to contribute to the onset of acute cardiovascular events. Several studies have suggested that RA confers a prothrombotic state featured by abnormalities in coagulation and fibrinolytic systems together with an altered state of platelet reactivity. It is conceivable that these findings may be partly instrumental for the observed increased risk for adverse cardiovascular events in RA. Therapeutic strategies aimed at attenuating the inflammatory disease activity and intervening at the point of cross-talk between mediators of inflammation and thrombogenesis may help reduce cardiovascular disease burden in patients with RA.