Progress towards tubes with regular nanopatterned inner surfaces
Progress towards tubes with regular nanopatterned inner surfaces
复制标题
具有规则纳米图案内表面的管材的进展
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
F. Romanato
中科院分区：
文献类型：
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作者：
K. Seunarine;M. Tormen;N. Gadegaard;M. Riehle;C. Wilkinson;L. Businaro;F. Romanato
血管的修复是组织工程中的一项重要任务。在微米和纳米尺度上，细胞的行为受到其附近表面拓扑结构的强烈影响。因此，作者希望制造出内表面有图案的管子。一种方法是利用x射线曝光的良好聚焦深度能力，在涂有抗蚀剂的曲面上打印直径为200nm、间距为400nm的点阵列。由这种结构制成的模具可以将纳米压印成可生物降解的聚合物。一个封闭的容器可以通过添加一个盖子来制造，这个盖子也有类似的纳米图案表面。给出了传递精度的细节。结果表明，x射线打印是一种适合于内部图案管形成的方法。
The repair of vascular tubing is an important task in tissue engineering. The behavior of cells is strongly influenced by the topology of the surfaces, on both a micrometric and a nanometric scale, in their vicinity. Thus the authors wish to make tubes that are patterned on the inner surface. One way to do this is to use the good depth of focus capabilities of x-ray exposure to print an array of dots, 200nm diameter and 400nm pitch, onto a curved surface coated in resist. A die made from this structure allows nanoembossing into a biodegradable polymer. A closed vessel can then be made by adding a lid, that also has a similar nanopatterned surface. Details of the accuracy of transfer are given. It is concluded that x-ray printing is a suitable approach for the formation of internally patterned tubing.