Acoustic Radiation Force Impulse Elastography in Determining the Effects of Type 1 Diabetes on Pancreas and Kidney Elasticity in Children
Acoustic Radiation Force Impulse Elastography in Determining the Effects of Type 1 Diabetes on Pancreas and Kidney Elasticity in Children
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DOI：
10.2214/ajr.17.18170
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发表时间：
2017-11-01
影响因子：
5
通讯作者：
Camlidag, Ilkay
中科院分区：
文献类型：
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作者：
Saglam, Dilek;Bilgici, Meltem Ceyhan;Camlidag, Ilkay
OBJECTIVE.本研究的目的是确定1型糖尿病对胰腺和肾脏弹性的儿童，使用声辐射力脉冲超声弹性成像。60例自身抗体阳性的1型糖尿病患者（45%女孩;平均[+/- SD]年龄，11.7 +/- 4.4岁;范围，1.9-19.3岁）和32例健康儿童（50%女孩;平均年龄，10.2 +/- 3.8岁;范围，2.1-17.3岁）被纳入本研究。对两组的肾脏和胰腺进行声辐射力脉冲弹性成像测量。记录1型糖尿病患者的体重指数、糖尿病病程、HbA 1c水平和胰岛素剂量。1型糖尿病患者胰腺的平均剪切波速度为0.99 +/- 0.25 m/s，健康对照组为1.09 +/- 0.22 m/s;差异不显著（p = 0.08）。1型糖尿病患者右肾和左肾的剪切波速度中位数分别为2.43 +/- 0.29和2.47 +/- 0.25 m/s。1型糖尿病患者和健康对照组的右肾和左肾剪切波速度无显著差异（分别为p = 0.91和p = 0.73）。相关分析显示1型糖尿病患者胰、肾剪切波速度与HbA 1c水平、糖尿病病程、胰岛素用量、身高、体重和体重指数无相关性。目前的研究表明，与健康对照组相比，正常白蛋白尿的1型糖尿病儿童的肾脏剪切波速度没有显着差异。我们还观察到，1型糖尿病儿童和健康对照组的胰腺剪切波速度没有显着差异。
OBJECTIVE. The aim of this study is to determine the effects of type 1 diabetes on pancreas and kidney elasticity in children, using acoustic radiation force impulse ultrasound elastography.SUBJECTS AND METHODS. Sixty autoantibody-positive patients with type 1 diabetes (45% girls; mean [+/- SD] age, 11.7 +/- 4.4 years; range, 1.9-19.3 years) admitted to the pediatric endocrinology outpatient clinic and 32 healthy children (50% girls; mean age, 10.2 +/- 3.8 years; range, 2.1-17.3 years) were included in the study. Acoustic radiation force impulse elastography measurements were performed of the kidneys and pancreas in both groups. Body mass index, duration of diabetes, HbA1c levels, and insulin dosage of patients with type 1 diabetes were recorded.RESULTS. The mean shear-wave velocities of the pancreas were 0.99 +/- 0.25 m/s in patients with type 1 diabetes and 1.09 +/- 0.22 m/s in healthy control subjects; the difference was not significant (p = 0.08). The median shear-wave velocities of the right and left kidneys in patients with type 1 diabetes were 2.43 +/- 0.29 and 2.47 +/- 0.25 m/s, respectively. There were no significant differences in the shear-wave velocities of the right and left kidneys between the patients with type 1 diabetes and the healthy control subjects (p = 0.91 and p = 0.73, respectively). Correlation analysis showed no correlation between the shear-wave velocities of the pancreas and kidney versus HbA1c level, duration of diabetes, insulin dosage, height, weight, and body mass index of the patients with type 1 diabetes.CONCLUSION. The current study showed no significant difference in the shear-wave velocity of kidneys in children with type 1 diabetes with normoalbuminuria compared with the healthy control subjects. We also observed that the shear-wave velocity of the pancreas in children with type 1 diabetes and healthy control subjects did not differ significantly.