Prevalence of hepatitis B virus genotype B in Vietnamese patients with chronic hepatitis B
Prevalence of hepatitis B virus genotype B in Vietnamese patients with chronic hepatitis B
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越南慢性乙型肝炎患者乙型肝炎病毒 B 基因型患病率
DOI：
10.1007/s12072-009-9141-2
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发表时间：
2009
影响因子：
6.6
通讯作者：
M. Nguyen
中科院分区：
文献类型：
--
作者：
L. Nguyen;N. Ha;P. Vutien;N. Ha;Ruel T. Garcia;H. Trinh;B. Levitt;Huy A. Nguyen;K. Nguyen;E. Keeffe;M. Nguyen
目的慢性B型肝炎（CH B）患者中，B型肝炎病毒（HBV）基因型可影响干扰素治疗的疗效和疾病转归。越南人是美国最大的少数民族之一，也是CHB和肝癌疾病负担最高的少数民族之一。本研究的目的是比较HBV基因型在越南和中国patients.MethodsWe的分布进行了一项横断面研究的567例连续患者的越南（n = 478）或中国（n = 89）血统，与HBV基因型突变分析之间进行7/2,005和6/2，结果越南人和中国人的平均年龄没有显著差异年龄（45岁和44岁）、性别（58%和61%男性）、HBeAg状态（64%和65%阴性）、中位丙氨酸氨基转移酶（33和41 U/L）和log 10 HBV DNA（4.9和5.0 log 10 IU/ml）或前核心/基本核心启动子突变的患病率（72%和71%）。越南患者B基因型的检出率（74%）高于中国患者（55%），C基因型的检出率（25%）低于中国患者（43%）（P = 0.001）。越南CH B患者大多具有HBV基因型B。需要进一步的研究来进一步描述越南慢性乙型肝炎患者HBV基因型在自然史和治疗结果中的临床意义。
PurposeHepatitis B virus (HBV) genotypes can affect treatment response to interferon-based therapy and disease outcomes in patients with chronic hepatitis B (CHB). Little data exist to characterize HBV genotypes in Vietnamese, one of the largest minority groups in the United States and also one with one of the highest CHB and liver cancer disease burdens. The goal of this study was to compare the distribution of HBV genotypes in Vietnamese and Chinese patients.MethodsWe performed a cross-sectional study of 567 consecutive patients of Vietnamese (n = 478) or Chinese (n = 89) descent, with HBV genotype mutation analysis performed between 7/2,005 and 6/2,008 at a community gastroenterology clinic and a university-affiliated liver clinic in the United States.ResultsThere were no significant differences between the Vietnamese and Chinese groups in mean age (45 and 44 years), gender (58% and 61% male), HBeAg status (64% and 65% negative), median alanine aminotransferase (33 and 41 U/L), and log10 HBV DNA (4.9 and 5.0 log10 IU/ml), or the prevalence of precore/basic core promoter mutations (72% and 71%), respectively. Vietnamese patients had a much higher prevalence of HBV genotype B and a lower prevalence of genotype C than Chinese patients: 74% and 25% vs. 55% and 43% (P = 0.001).ConclusionsChinese patients with CHB often carry either B or C genotype. Vietnamese patients with CHB mostly have HBV genotype B. Additional studies are needed to further characterize the clinical significance of HBV genotype in the natural history and treatment outcomes of CHB in Vietnamese patients.