Plasma levels of endothelin-1 increase in patients with sarcoidosis and fall after disease remission.
Plasma levels of endothelin-1 increase in patients with sarcoidosis and fall after disease remission.
复制标题
结节病患者血浆内皮素-1 水平升高，疾病缓解后下降。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
E. D'erasmo
中科院分区：
文献类型：
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作者：
Claudio Letizia;A. Danese;M. G. Reale;C. Caliumi;E. Delfini;S. Subioli;S. Cerci;E. D'erasmo
背景
结节病是一种慢性全身性疾病，其特征是免疫过程失衡和肉芽肿的存在。内皮素-1是一种新的血管活性和支气管收缩多肽，是一种强大的平滑肌细胞和成纤维细胞有丝分裂原，在炎症状态中发挥作用。我们推测内皮素-1在结节病中起一定作用。
方法
本文研究了20例结节病患者循环内皮素-1的动态变化及其与活动性疾病的血沉、血清血管紧张素转换酶等生化指标的关系。在研究开始时，我们检测了所有患者的血清ESR、SACE、钙和血浆内皮素-1水平，并对9例激素治疗后临床生化缓解的患者再次进行了检测。
结果
在结节病患者中，循环内皮素-1、血沉和血沉水平显著高于健康人(p<；0.001)。此外，在肺部受累的患者中，与正常受试者相比，内皮素-1水平和放射学分期之间有显著的统计学差异(p<；0.001)。9例病情缓解的患者，内皮素-1水平和疾病活动期指标均恢复正常。
结论
我们的结果似乎表明，活动性结节病患者血浆内皮素-1水平的升高可以代表内皮功能障碍的一种表现，并反映了细胞激活的图景。
BACKGROUND
Sarcoidosis is a chronic systemic disease, characterized by an imbalance of immunity processes and the presence of granuloma. Endothelin-1, a new vasoactive and bronchoconstrictive peptide, is a powerful mitogen for smooth muscle cells and fibroblasts and plays a role in the inflammation state. We postulate that endothelin-1 has a role in sarcoidosis.
METHODS
We studied the behaviour of circulating levels of endothelin-1 in 20 patients with sarcoidosis and its correlation with some biochemical parameters of activity disease, such as erythrocyte sedimentation rate (ESR) and serum angiotensin-converting enzyme (SACE). We measured serum levels of ESR, SACE, calcium and plasma endothelin-1 levels in all patients at the beginning of the study and one again in 9 patients with clinical-biochemical remission of disease after steroid treatment.
RESULTS
In patients with sarcoidosis, circulating levels of endothelin-1, SACE and ESR were significantly higher (p<0.001) than those of healthy subjects. Moreover, in patients with pulmonary involvement, there was a significant statistical difference (p<0.001) between endothelin-1 levels and radiological stage compared to normal subjects. In the 9 patients with remission of disease, both endothelin-1 levels and parameters of activity disease normalized.
CONCLUSIONS
Our results seem to suggest that the increase of plasma endothelin-1 levels in active sarcoidosis can represent an expression of the endothelial dysfunction and reflect the picture of cellular activation.