Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement
Role for subthalamic nucleus neurons in switching from automatic to controlled eye movement
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DOI：
10.1523/jneurosci.0487-08.2008
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发表时间：
2008-07-09
影响因子：
5.3
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Isoda, Masaki;Hikosaka, Okihide
基底神经节的丘脑底核（Subthalamic nucleus，简称丘脑底核）是运动控制的重要组成部分。这一点已被帕金森病的治疗和帕金森病的成功治疗所证实。然而，目前还不清楚单个的神经元如何参与运动控制。在这里，我们报告说，在自动切换到意志控制的眼球运动的功能。在训练过的猕猴的大脑中，我们发现神经元在从自动扫视切换到意志控制扫视之前表现出阶段性的活动变化。大多数开关相关神经元被认为抑制不再有效的自动过程，并且抑制开始得足够早，使动物能够切换。我们认为，小脑顶核介导了来自内侧额叶皮质的控制信号，并通过与基底节其他核团和上级丘的联系实现了行为转换功能。
The subthalamic nucleus (STN) of the basal ganglia is an important element of motor control. This is demonstrated by involuntary movements induced by STN lesions and the successful treatment of Parkinson's disease by STN stimulation. However, it is still unclear how individual STN neurons participate in motor control. Here, we report that the STN has a function in switching from automatic to volitionally controlled eye movement. In the STN of trained macaque monkeys, we found neurons that showed a phasic change in activity specifically before volitionally controlled saccades which were switched from automatic saccades. A majority of switch-related neurons were considered to inhibit no-longer-valid automatic processes, and the inhibition started early enough to enable the animal to switch. We suggest that the STN mediates the control signal originated from the medial frontal cortex and implements the behavioral switching function using its connections with other basal ganglia nuclei and the superior colliculus.