Selenium and intractable epilepsy: Is there any correlation?
Selenium and intractable epilepsy: Is there any correlation?
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DOI：
10.1016/j.pediatrneurol.2006.09.001
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发表时间：
2007-01-01
影响因子：
3.8
通讯作者：
Pourpak, Zahra
中科院分区：
文献类型：
--
作者：
Ashrafi, Mahmood Reza;Shabanian, Reza;Pourpak, Zahra
氧化应激和活性氧的产生与包括癫痫在内的许多神经元和神经肌肉疾病密切相关。硒作为一种抗氧化微量元素的功能被认为是通过硒蛋白来实现的，硒蛋白具有抗氧化活性和促进神经元细胞存活的能力。由于硒对氧化损伤的保护作用，我们设计了一项病例对照研究，比较难治性癫痫患者和正常人的血清硒水平。80例符合顽固性癫痫标准的患者与相同年龄、社会经济水平和居住地的正常对照组进行比较。用原子吸收分光光度计测定血清硒水平。患者和对照组血清硒的平均（+/- sd）分别为68.88 (+/- 17.58)ng/mL和85.93 (+/- 13.93)ng/mL。独立样本t检验P < 0.05，患者组血清硒均值显著低于正常对照组。然而，血清硒与一些建议的顽固性癫痫发作的预测因素，包括癫痫发作的年龄、新生儿癫痫发作、神经功能障碍和癫痫病因之间没有关联。难治性癫痫患者应考虑血清硒的测定。(c) 2007年Elsevier Inc.版权所有。
Oxidative stress and generation of reactive oxygen species are strongly implicated in a number of neuronal and neuromuscular disorders, including epilepsy. The functions of selenium as an antioxidant trace element are believed to be carried out by selenoproteins that possess antioxidant activities and the ability to promote neuronal cell survival. Because of this protective role of selenium against oxidative damage, a case-control study was designed to compare its serum level between intractable epileptic patients and normal subjects. Eighty patients who met the criteria of intractable epilepsy were compared with a normal control group of the same age, socioeconomic level, and place of living. Serum selenium level was measured with an atomic absorption spectrophotometer. The mean (+/- S.D.) of serum selenium were 68.88 (+/- 17.58) ng/mL and 85.93 (+/- 13.93) ng/mL in the patient and control groups respectively. Independent sample t test with P < 0.05 indicated a significant lower mean of serum selenium in the patient group compared with that of the normal control group. However, there was no association between serum selenium and some suggested predictive factors of intractable seizures, including age at the onset of seizures, neonatal seizure, neurologic impairment, and etiology of epilepsy. Measurement of serum selenium in patients with intractable epilepsy should be considered. (c) 2007 by Elsevier Inc. All rights reserved.