Radiation induced degradation of antiepileptic drug primidone in aqueous solution
Radiation induced degradation of antiepileptic drug primidone in aqueous solution
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DOI：
10.1016/j.cej.2015.01.120
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发表时间：
2015-06
影响因子：
15.1
通讯作者：
Ning Liu;Tao Wang;M. Zheng;Jianqiu Lei;L. Tang;Gu-yu Hu;Gang Xu;Minghong Wu
中科院分区：
文献类型：
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作者：
Ning Liu;Tao Wang;M. Zheng;Jianqiu Lei;L. Tang;Gu-yu Hu;Gang Xu;Minghong Wu
本研究旨在研究电子束辐照对抗癫痫药物扑米酮(PMD)在水溶液中的降解效果。结果表明，PMD的降解符合准一级动力学。实验测得的剂量常数范围为1.2 6~4.5 9kGyPMD 1，并随偏振模色散初始浓度的增加而减小，而偏振模色散初始辐射化学产额随吸收剂量的增加而减小，随偏振模色散浓度的增加而增加。考察了介质pH、SO42-−、SO32-−、CO32-−、HCO3-−、NO3-−和NO2-−阴离子、H_2O_2、异丙醇和N_2、O_2、N_2O饱和溶液的存在对反应的影响。结果表明，热还原DOTOH对PMD的降解起主要作用，还原的Eaq−和自由基DOH对PMD的降解起次要作用。用LC/MS/MS和IC检测到PMD的主要降解产物，包括降解中间体、低质量有机酸和一些无机离子。辐照后的溶液中含有甲酸、醋酸、草酸、顺丁烯二酸和NO3-−、NH4+。提出了水溶液中电子束辐照分解PMD的可能途径。
The present study was to determine the effectiveness of electron beam irradiation for degradation of the antiepileptic drug primidone (PMD) in aqueous solution. The results showed that PMD degradation followed pseudo-first-order kinetics. The dose constant determined in this study ranged from 1.26 to 4.59 kGy−1, and decreased with an increase in the PMD initial concentration, whereas the initial radiation chemical yield for the loss of PMD decreased with increasing of absorbed dose and increased as the PMD concentration increased. The effects of medium pH, the presence of SO42−, SO32−, CO32−, HCO3−, NO3−and NO2−anions, H2O2, iso-propanol, and saturated solutions of N2, O2, N2O were also investigated. The results demonstrated that theradical dotOH took the most important role in the degradation of PMD, while the reductive eaq−andradical dotH took the less important role in PMD degradation. Major degradation products of PMD, including degradation intermediates, low weight organic acids and some inorganic ions were detected by LC/MS/MS and IC. Formic acid, acetic acid, oxalic acid, maleic acid and NO3−, NH4+were identified in the irradiated solutions. Possible pathways for PMD decomposition by electron beam irradiation in aqueous solution were proposed.