Clinical and immunologic characteristics of Vibrio cholerae O139 Bengal infection in North American volunteers.
Clinical and immunologic characteristics of Vibrio cholerae O139 Bengal infection in North American volunteers.
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北美志愿者中孟加拉霍乱弧菌 O139 感染的临床和免疫学特征。
DOI：
10.1093/infdis/171.4.903
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Levin,MM
中科院分区：
文献类型：
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作者：
MorrisJr,JG;Losonsky,GE;Johnson,JA;Tacket,CO;Nataro,JP;Panigrahi,P;Levin,MM
O139孟加拉霍乱弧菌最近成为亚洲流行霍乱的一个原因。为了评估对感染的临床和免疫学反应，对健康的成年北美志愿者接种了O139孟加拉霍乱弧菌AIl837。摄入104cfu的4人中有2人患病(潜伏期48小时；平均腹泻大便1873克)，服用106 cfu的9人中有7人患病(潜伏期28小时；平均腹泻大便4548克)。III志愿者没有表现出对挑战菌株或其他V的杀弧性抗体反应。霍乱弧菌。三个月后，志愿者被再次挑战同源O139孟加拉病毒株。在最初攻击时患病的6人中只有1人出现腹泻，而13名对照组中有11人出现腹泻(P=.01；保护效果=80%)。O139孟加拉霍乱弧菌可引起典型的霍乱严重腹泻，其临床特征和剂量反应与V型霍乱相似。霍乱O1E1Tor.最初的临床感染提供了对后续疾病的中等高水平的保护。
Vibrio choleraeO139 Bengal has recently emerged as a cause of epidemic cholera in Asia. To evaluate clinical and immunologic responses to infection,V. choleraeO139 Bengal AIl837 was administered to healthy adult North American volunteers. Two of 4 persons ingesting 104cfu became ill (incubation period, 48 h; mean diarrheal stool, 1873 g), as did 7 of9 persons receiving 106cfu (incubation period, 28 h; mean diarrheal stool, 4548 g). III volunteers did not demonstrate a vibriocidal antibody response to the challenge strain or otherV. cholerae. Three months later, volunteers were rechallenged with the homologous O139 Bengal strain. Only 1 of 6 persons who had been ill on initial challenge had diarrhea, compared with 11 of 13 controls (P= .01; protective efficacy = 80%).V. choleraeO139 Bengal can cause severe diarrhea typical of cholera, with clinical characteristics and a dose-response similar to those seen withV. choleraeO1 E1 Tor. A moderately high level of protection against subsequent disease is provided by initial clinical infection.