Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders
Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders
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DOI：
10.4161/cbt.4.11.2087
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发表时间：
2005-11-01
影响因子：
3.6
通讯作者：
Mazzarino, MC
中科院分区：
文献类型：
--
作者：
Libra, M;Indelicato, M;Mazzarino, MC
丙型肝炎病毒（HCV）感染与慢性肝炎、肝硬化和肝细胞癌有关。最近的证据也表明，HCV感染有助于自身免疫性疾病和B细胞非霍奇金淋巴瘤（NHL）的发展。HCV感染促进B细胞NHL发展的机制尚不清楚。血清骨桥蛋白（OPN）水平升高与多种自身免疫性疾病以及多种癌症相关。然而，OPN与B细胞NHL或HCV相关的B细胞增殖之间的关联以前尚未报道。在本研究中，我们确定血清OPN差异是否与HCV感染、II型混合性冷球蛋白血症（MC）综合征和B细胞NHL相关。采用捕获酶联免疫吸附法测定血清OPN水平。我们的研究结果表明，高血清OPN水平与B细胞NHL和HCV感染有关。有趣的是，最高的血清OPN浓度被发现在HCV感染的患者伴随II型MC综合征与B细胞NHL。这些数据表明，OPN参与淋巴瘤的发生，特别是在HCV感染和自身免疫性疾病的背景下。
Hepatitis C virus ( HCV) infection is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Recent evidences have also suggested that HCV infection contributes to development of autoimmune disorders and B-cell nonHodgkin's lymphoma ( NHL). Mechanisms by which HCV infection promotes B-cell NHL development remain unclear. Increased serum osteopontin ( OPN) levels have been associated with several autoimmune diseases as well as a variety of cancers. However, the association between OPN and B-cell NHL or HCV-associated B-cell proliferation has not previously been reported. In the present study, we determined whether serum OPN differences were associated with HCV infection, type II mixed cryglobulinemia ( MC) syndrome and B-cell NHL. Serum OPN levels were measured by capture enzyme-linked immunosorbent assay. Our results show that high serum OPN levels are associated with B-cell NHL and HCV infection. Interestingly, highest serum OPN concentrations were found among HCV-infected patients with concomitant type II MC syndrome with and without B-cell NHL. These data indicate that OPN is involved in the lymphomagenesis, especially, in the context of HCV infection and autoimmune diseases.