Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats.
Effect of piroxicam on the blood-retina barrier in experimentally induced diabetes in rats.
复制标题
吡罗昔康对实验性糖尿病大鼠血视网膜屏障的影响。
DOI：
10.1007/bf00128953
复制
发表时间：
1991
影响因子：
1.6
通讯作者：
Khoobehi,B
中科院分区：
文献类型：
--
作者：
Bahgat,M;Anis,HH;Peyman,GA;Farahat,HG;Parry,GJ;Khoobehi,B
在实验诱发糖尿病的大鼠中评估了吡罗昔康对血视网膜屏障的影响。通过腹腔注射链脲佐菌素（STZ）诱发大鼠糖尿病。糖尿病大鼠被分为两个相等的组：用吡罗昔康（一种长效血小板抑制剂）治疗的组和未经治疗的对照组。在诱导糖尿病和吡罗昔康摄入之前和之后两周进行玻璃体荧光光度测定（VFP）。与正常大鼠相比，链佐菌素诱导的糖尿病引起血视网膜屏障的改变，其证据是糖尿病大鼠玻璃体荧光素浓度增加。吡罗昔康摄入不会导致玻璃体荧光素浓度发生显着变化。然而，由于白内障形成，检查不得不在两周后终止。吡罗昔康治疗组的晶状体混浊形成率较低（59.1%，而未治疗组为 81.8%，p = 0.0006）。给予吡罗昔康似乎可以保护糖尿病大鼠的眼睛免受晶状体浑浊的影响。
The effect of piroxicam on the blood-retina barrier was evaluated in rats with experimentally induced diabetes. Diabetes was induced in rats by intraperitoneal injection of streptozocin (STZ). Diabetic rats were divided into two equal groups: those treated with piroxicam, a long-acting platelet inhibitor, and an untreated control group. Vitreous fluorophotometry (VFP) was performed both before and two weeks after induction of diabetes and piroxicam intake. Streptozocin-induced diabetes caused an alteration in the blood-retinal barrier evidenced by an increase in vitreous fluorescein concentration in diabetic rats compared with normal rats. Piroxicam intake did not lead to significant change in vitreous fluorescein concentrations. However, the examination had to be terminated at two weeks because of cataract formation. The piroxicam treated group showed less incidence of lens opacity formation (59.1% compared to 81.8% in the untreated group, p = 0.0006). Piroxicam administration appears to protect the diabetic rat eye against lens opacification.