Chronic stress at work and the metabolic syndrome: prospective study
Chronic stress at work and the metabolic syndrome: prospective study
复制标题
DOI：
10.1136/bmj.38693.435301.80
复制
发表时间：
2006-03-04
影响因子：
105.7
通讯作者：
Marmot, M
中科院分区：
文献类型：
--
作者：
Chandola, T;Brunner, E;Marmot, M
目的探讨工作压力与代谢综合征的关系。设计前瞻性队列研究，研究工作压力与代谢综合征的关系。受试者为10 308名男性和女性，年龄35-55岁，在伦敦20个公务员部门工作(白厅11号研究)；平均随访14年。主要结果基于等应变模型，在四个场合(1985-99)测量工作压力。结果14年以上的工作应激源暴露与代谢综合征的风险之间存在剂量-反应关系，不受其他相关危险因素的影响。有长期工作压力(3次或3次以上)的员工患代谢综合征的几率是无工作压力员工的两倍以上(按年龄和工作级别调整的优势比为2.25，95%可信区间为1.31~3.85)。结论工作压力是代谢综合征的重要危险因素。这项研究为日常生活中的心理社会应激源与心脏病之间的联系提供了生物学上可信的证据。
Objectives To investigate the association between stress at work and the metabolic syndrome.Design Prospective cohort study investigating the association between work stress and the metabolic syndrome.Participants 10 308 men and women, aged 35-55, employed in 20 London civil service departments at baseline (the Whitehall 11 study); follow-up was an average of 14 years.Main outcome measures Work stress based on the iso-strain model, measured on four occasions (1985-99). Biological measures of the metabolic syndrome, based on the National Cholesterol Education Program definition, measured in 1999.Results A dose-response relation was found between exposure to work stressors over 14 years and risk of the metabolic syndrome, independent of other relevant risk factors. Employees with chronic work stress (three or more exposures) were more than twice as likely to have the syndrome than those without work stress (odds ratio adjusted for age and employment grade 2.25, 95% confidence interval 1.31 to 3.85).Conclusions Stress at work is an important risk factor for the metabolic syndrome. The study provides evidence for the biological plausibility of the link between psychosocial stressors from everyday life and heart disease.