DYNORPHIN A-(1-13) ATTENUATES WITHDRAWAL IN MORPHINE-DEPENDENT RATS - EFFECT OF ROUTE OF ADMINISTRATION
DYNORPHIN A-(1-13) ATTENUATES WITHDRAWAL IN MORPHINE-DEPENDENT RATS - EFFECT OF ROUTE OF ADMINISTRATION
复制标题
DOI：
10.1016/0014-2999(88)90429-3
复制
发表时间：
1988-01-19
影响因子：
5
通讯作者：
LEE, NM
中科院分区：
文献类型：
--
作者：
GREEN, PG;LEE, NM
通过皮下植入吗啡生物碱颗粒使大鼠对吗啡耐受。颗粒植入后3天，通过取出颗粒诱导戒断，并在6小时后进行评估。在即将进行戒断评估之前，向大鼠i.th. (via导管）、i. c. v.（通过插管）或i. v.（通过尾静脉）。当i.t.在1.25-5 nmol/大鼠的剂量范围内，强啡肽A-（1-13）在40分钟的观察期内减弱戒断。类似地，强啡肽A-（1-13）在40分钟观察期内减弱戒断。类似地，静脉内给予强啡肽A-（1-13）（37.5-150 nmol/kg）减弱了戒断，尽管仅在给药后的前20分钟内。强啡肽A-（1-13）高达10 nmol/大鼠对戒断评分无影响。这些数据表明，强啡肽作用于脊髓部位，抑制吗啡依赖大鼠的戒断反应，并可能在耐受和依赖机制中发挥作用。
Rats were made tolerant to morphine by subcutaneous implantation of morphine alkaloid pellets. Three days after pellet implantation, withdrawal was induced by pellet removal and was assessed 6 h later. Immediately prior to withdrawal assessment, rats were injected with dynorphin A-(1-13) either i.th. (via a catheter), i.c.v. (via a cannula) or i.v. (via the tail vein). When administered i.th. in the dose range 1.25-5 nmol/rat, dynorphin A-(1-13) attenuated withdrawal over the 40 min observation period. Similarly, dynorphin A-(1-13) attenuated withdrawal over the 40 min observation period. Similarly, dynorphin A-(1-13) administered i.v. (37.5-150 nmol/kg) attenuated withdrawal, though only over the first 20 min following administration. Dynorphin A-(1-13) up to 10 nmol/rat had no effect on withdrawal scores. These data indicate that dynorphin acts at spinal sites to suppress withdrawal in morphine-dependent rats and may play a role in tolerance and dependence mechanisms.