Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: Results from a multi-ethnic cohort
Association of novel biomarkers with future cardiovascular events is influenced by ethnicity: Results from a multi-ethnic cohort
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DOI：
10.1016/j.ijcard.2011.11.034
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发表时间：
2013-06-20
影响因子：
3.5
通讯作者：
Afonso, Luis
中科院分区：
文献类型：
--
作者：
Veeranna, Vikas;Zalawadiya, Sandip K.;Afonso, Luis
背景资料：我们试图在多种族动脉粥样硬化研究（梅萨）研究参与者中确定种族对新型生物标志物和心血管疾病（CVD）事件之间关联的影响，该研究参与者是一个以社区为基础的无症状美国成人人群。基线生物标志物即C-反应蛋白（CRP）、纤维蛋白原、白细胞介素-6（IL-6）、D-二聚体、纤溶酶-抗纤溶酶复合物（PAP）和因子VIII被用于根据Cox比例风险分析预测种族分层研究队列中所有CVD事件的累积发生率，其中模型针对相关混杂因素进行了调整。种族队列包括2362名白人，1601名非洲裔美国人，1353名西班牙裔和751名中国人。在平均4.6年的随访中，共发现286例心血管事件，高加索人的累积发病率为11.3%，非洲裔美国人为9.8%，西班牙裔美国人为11.3%，中国人为6.9%。（HR，95% CI，p值）显示：仅白人中的CRP（1.23，1.04-1.47，
Background: We sought to define the influence of ethnicity on associations between novel biomarkers and cardiovascular disease (CVD) events among Multi-Ethnic Study of Atherosclerosis (MESA) study participants, a community based population of asymptomatic US adults.Methods: Baseline (log transformed) levels of biomarkers namely C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), D-dimer, plasmin-antiplasmin complex (PAP) and factor VIII were used to predict the cumulative incidence of all CVD events in an ethnicity stratified study cohort from Cox-proportional hazard analysis where models were adjusted for relevant confounders.Results: Ethnic cohorts included 2362 Caucasians, 1601 African Americans, 1353 Hispanics, and 751 Chinese. At mean 4.6 years of follow-up, 286 CVD events were identified with cumulative incidence of 11.3% in Caucasians, 9.8% in African Americans, 11.3% in Hispanics and 6.9% in Chinese.Biomarker risk association with CVD events incidence was significantly influenced by ethnicity with positive association (HR, 95% CI, p value) being shown for: CRP among Caucasians only (1.23, 1.04-1.47,