Nucleic acid-sensing TLRs: trafficking and regulation.
Nucleic acid-sensing TLRs: trafficking and regulation.
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DOI：
10.1016/j.coi.2016.10.003
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发表时间：
2017-02
影响因子：
7
通讯作者：
Barton GM
中科院分区：
文献类型：
--
作者：
Majer O;Liu B;Barton GM
Toll样受体在抵抗病原微生物或组织损伤的先天免疫反应中发挥着重要作用。核酸(NA)敏感的TLRs定位于细胞内的囊泡室，识别外源和宿主来源的核苷酸。NA敏感的TLRs的不适当激活可导致致病性炎症和自身免疫。存在多种调节机制来限制对自我NAS的识别。本文综述了最近在理解NA敏感的TLRs如何通过贩运、蛋白水解性切割以及配体处理和识别来调节方面的最新进展。
Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign- and host-derived nucleotides. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition.