Factors contributing to the rise of buprenorphine misuse: 2008-2013
Factors contributing to the rise of buprenorphine misuse: 2008-2013
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DOI：
10.1016/j.drugalcdep.2014.06.005
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发表时间：
2014-09-01
影响因子：
4.2
通讯作者：
Kurtz, Steven P.
中科院分区：
文献类型：
--
作者：
Cicero, Theodore J.;Ellis, Matthew S.;Kurtz, Steven P.
目的：本研究的目的是研究丁丙诺啡在治疗渠道外使用的动机，以及可能导致近年来丁丙诺啡滥用迅速增加的因素。方法：(1)采用混合方法，对全国进入阿片类药物依赖药物滥用治疗项目的患者进行结构化、自我管理的调查（N = 10,568）和反身性、定性访谈（N = 208），以阿片类药物滥用模式和相关行为为中心；(2)与全国30个执法机构就其管辖范围内的主要转移毒品进行了访谈。结果：我们的研究结果表明，丁丙诺啡的滥用在过去5年中大幅增加，特别是在上个月的海洛因使用者中。我们的定量和定性数据表明，最近丁丙诺啡滥用的增加主要是由于它为滥用阿片类药物的人群提供了多种功能：获得快感，管理戒断病，替代更喜欢的药物，治疗疼痛，管理精神问题，并作为一种自我指导的努力来戒掉阿片类药物。结论：在过去的五年中，丁丙诺啡的非治疗性使用急剧上升，特别是那些同时使用海洛因的人。然而，丁丙诺啡似乎很少因其固有的致欣快性而受到青睐，而是作为其他药物，特别是海洛因的替代品，或作为一种比美沙酮更可取的药物，用于自我治疗戒断病或戒断阿片类药物。2014爱思唯尔爱尔兰有限公司版权所有。
Objective: The purpose of the present study was to examine the motivations underlying the use of buprenorphine outside of therapeutic channels and the factors that might account for the reported rapid increase in buprenorphine misuse in recent years.Methods: This study used: (1) a mixed methods approach consisting of a structured, self-administered survey (N = 10,568) and reflexive, qualitative interviews (N = 208) among patients entering substance abuse treatment programs for opioid dependence across the country, centered on opioid misuse patterns and related behaviors; and (2) interviews with 30 law enforcement agencies nationwide about primary diverted drugs in their jurisdictions.Results: Our results demonstrate that the misuse of buprenorphine has increased substantially in the last 5 years, particularly amongst past month heroin users. Our quantitative and qualitative data suggest that the recent increases in buprenorphine misuse are due primarily to the fact that it serves a variety of functions for the opioid-abusing population: to get high, manage withdrawal sickness, a's a substitute for more preferred drugs, to treat pain, manage psychiatric issues and as a self-directed effort to wean themselves off opioids.Conclusion: The non-therapeutic use of buprenorphinehas risen dramatically in the past five years, particularly in those who also use heroin. However, it appears that buprenorphine is rarely preferred for its inherent euphorigenic properties, but rather serves as a substitute for other drugs, particularly heroin, or as a drug used, preferable to methadone, to self-medicate withdrawal sickness or wean off opioids. (C) 2014 Elsevier Ireland Ltd. All rights reserved.