Emerging roles of extracellular vesicles in normal and malignant hematopoiesis.
Emerging roles of extracellular vesicles in normal and malignant hematopoiesis.
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细胞外囊泡在正常和恶性造血中的新作用
DOI：
10.1172/jci160840
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发表时间：
2022-09-15
影响因子：
15.9
通讯作者：
Cheng, Tao
中科院分区：
文献类型：
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作者：
Sun, Guohuan;Gu, Quan;Zheng, Junke;Cheng, Hui;Cheng, Tao
造血干细胞受其微环境（或“生态位”）的调节，维持成熟血液和免疫细胞的产生。白血病细胞重塑微环境以提高其存活率，这伴随着血液恶性肿瘤中正常造血支持的丧失。细胞外囊泡（EV）在生理和病理条件下介导细胞间通讯，并破译其在生态系统中细胞-细胞相互作用中的功能可以突出潜在的治疗靶点。在这篇综述中，我们说明了来自各种细胞类型的EV的效用，重点是它们所包含的生物分子和它们可以在受体细胞中诱导的行为改变。我们还讨论了在血液恶性肿瘤中的临床应用潜力，包括基于EV的治疗方案，通过EV的药物递送，以及EV（或其货物）作为生物标志物的使用。
Hematopoietic stem cells, regulated by their microenvironment (or “niche”), sustain the production of mature blood and immune cells. Leukemia cells remodel the microenvironment to enhance their survival, which is accompanied by the loss of support for normal hematopoiesis in hematologic malignancies. Extracellular vesicles (EVs) mediate intercellular communication in physiological and pathological conditions, and deciphering their functions in cell-cell interactions in the ecosystem can highlight potential therapeutic targets. In this Review, we illustrate the utility of EVs derived from various cell types, focusing on the biological molecules they contain and the behavioral alterations they can induce in recipient cells. We also discuss the potential for clinical application in hematologic malignancies, including EV-based therapeutic regimens, drug delivery via EVs, and the use of EVs (or their cargoes) as biomarkers.