EVIDENCE THAT GLUCOSE MARKS BETA-CELLS RESULTING IN PREFERENTIAL RELEASE OF NEWLY SYNTHESIZED INSULIN
EVIDENCE THAT GLUCOSE MARKS BETA-CELLS RESULTING IN PREFERENTIAL RELEASE OF NEWLY SYNTHESIZED INSULIN
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DOI：
10.1126/science.6181562
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
GRODSKY, GM
中科院分区：
文献类型：
--
作者：
GOLD, G;GISHIZKY, ML;GRODSKY, GM
对用放射性亮氨酸标记的分离胰岛的研究表明，葡萄糖在关键时间对胰岛进行标记，从而导致新合成的胰岛素优先释放。从标记的胰岛优先释放胰岛素相对独立于随后的促分泌剂或胰岛素分泌速率。先前的动力学研究表明，标记发生的关键时间是在胰岛素原生物合成之后、分泌事件之前。因此，分泌细胞可以调节新合成材料的转移，以便在其接近或通过高尔基体时立即释放。
Studies of isolated islets labeled with radioactive leucine show that glucose at a critical time marks islets in such a way as to cause preferential release of newly synthesized insulin. The preferential release of insulin from marked islets is relatively independent of subsequent secretagogues or rates of insulin secretion. Previous kinetic studies have indicated that the critical time at which marking occurs is after proinsulin biosynthesis but before the secretory event. Thus, secretory cells may regulate the diversion of newly synthesized material for immediate release as it is approaching or transiting the Golgi apparatus.