Distribution and morphological characteristics of the interstitial cells of Cajal in the ileocaecal junction of the guinea-pig

Distribution and morphological characteristics of the interstitial cells of Cajal in the ileocaecal junction of the guinea-pig
复制标题

DOI：
10.1007/s00441-009-0854-2
复制
发表时间：
2009-09
期刊：
Cell and Tissue Research
影响因子：
3.6
通讯作者：
Sachiko Miyamoto-Kikuta;T. Ezaki;T. Komuro
Sachiko Miyamoto-Kikuta;T. Ezaki;T. Komuro
中科院分区：
生物学3区
文献类型：
--
作者：
Sachiko Miyamoto-Kikuta;T. Ezaki;T. Komuro

文献摘要

相似文献

用免疫组织化学方法研究了豚鼠回盲部（包括回盲瓣）的肌束、肠神经和Cajal间质细胞（ICC）的组织结构。该区域ICC的分布具有明显的特征性：（1）回肠末端回盲部增厚处，环肌层（ICC-CM）和纵肌层（ICC-LM）ICC较多，其余回肠ICC较少或不存在;（2）回肠侧与小肠一样含有与深肌丛相关的ICC（ICC-CM），而盲肠侧与盲肠一样不含ICC-CM，（3）回肠和盲肠侧均含有大量ICC-CM和ICC-LM;（4）在回肠和盲肠两侧均可见与肌间神经丛相关的ICC，而盲肠内仅可见少量ICC;（5）在回肠末端和回盲瓣的局限区域内，ICC也可见于粘膜下神经丛周围。这些观察结果提供了形态学证据，末端回肠和回盲瓣是专门装备的，他们积极参与运动的交界区。
The guinea-pig ileocaecal junction including the valve was studied by immunohistochemistry to clarify the organization of the muscle bundles, the enteric nerves and the interstitial cells of Cajal (ICC). This region clearly exhibited characteristic features in the distribution patterns of ICC in a proximal to distal direction: (1) the thickened portion of the terminal ileum immediately adjacent to the ileocecal junction contained many ICC throughout the circular (ICC-CM) and longitudinal (ICC-LM) muscle layers, but ICC were few or absent in the rest of the ileum; (2) the ileal side of the valve contained ICC associated with the deep muscular plexus (ICC-DMP) as in the small intestine, whereas ICC-DMP were absent in the caecal side as in the caecum; (3) the valve contained many ICC-CM and ICC-LM in both the ileal and caecal sides; (4) many ICC associated with the myenteric plexus were observed in both the ileal and caecal sides of the valve, whereas they were only sparsely found in the caecum; (5) ICC were also observed around the submucosal plexus in a confined area of the terminal ileum and the ileocaecal valve. These observations provide morphological evidence that the terminal ileum and ileocaecal valve are specially equipped for their active involvement in the movement of the junctional area.