Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex
Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex
复制标题
DOI：
10.1523/jneurosci.19-20-09029.1999
复制
发表时间：
1999-10-15
影响因子：
5.3
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Rogers, RD;Owen, AM;Robbins, TW
眼眶前额叶皮层 (PFC) 持续受损的患者在实验室赌博或冒险任务的表现方面表现出明显的损害，这表明人类 PFC 的这一部分有助于决策认知。然而，迄今为止，人们对参与这一功能的眼眶皮层的特定区域知之甚少。在本研究中，使用 H-2 O-15 PET 技术对 8 名健康志愿者进行扫描，同时执行一项新颖的计算机化冒险任务。该任务涉及预测两个互斥结果中的哪一个会发生，但至关重要的是，较大的奖励（和惩罚）与选择最不可能的结果相关，而最小的奖励（和惩罚）与选择最可能的结果相关。解决这些“冲突”的决定与右下和眶PFC内区域脑血流量增加的三个不同焦点相关：横向，额中回前部[布罗德曼区10（BA 10）]，内侧，眶回（BA 11），后方，额下回前部（BA 47）。相比之下，这些决定中固有的冲突程度的增加仅与眼眶前额皮层和前扣带皮层内的活动发生有限的变化相关。这些结果表明，决策过程会从下前额皮质的多个区域中招募神经活动，这些区域从不同的皮质和边缘输入中接收信息，并且眶额区域的贡献可能涉及处理与奖励相关的信息的变化。
Patients sustaining lesions of the orbital prefrontal cortex (PFC) exhibit marked impairments in the performance of laboratory-based gambling, or risk-taking, tasks, suggesting that this part of the human PFC contributes to decision-making cognition. However, to date, little is known about the particular regions of the orbital cortex that participate in this function. In the present study, eight healthy volunteers were scanned, using H-2 O-15 PET technology, while performing a novel computerized risk-taking task. The task involved predicting which of two mutually exclusive outcomes would occur, but critically, the larger reward (and penalty) was associated with choice of the least likely outcome, whereas the smallest reward (and penalty) was associated with choice of the most likely outcome. Resolving these "conflicting" decisions was associated with three distinct foci of regional cerebral blood flow increase within the right inferior and orbital PFC: laterally, in the anterior part of the middle frontal gyrus [Brodmann area 10 (BA 10)], medially, in the orbital gyrus (BA 11), and posteriorly, in the anterior portion of the inferior frontal gyrus (BA 47). By contrast, increases in the degree of conflict inherent in these decisions was associated with only limited changes in activity within orbital PFC and the anterior cingulate cortex. These results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information.