Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects
Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects
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DOI：
10.1007/s00213-003-1766-6
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发表时间：
2004-07-01
影响因子：
3.4
通讯作者：
Rodenbeck, A
中科院分区：
文献类型：
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作者：
Cohrs, S;Pohlmann, K;Rodenbeck, A
理由。下丘脑-垂体-肾上腺（HPA）轴功能障碍是精神疾病（包括精神病性抑郁症和精神分裂症）的常见表现。关于抗精神病药物对HPA轴的影响，存在明确的结果。Objective.因此，这项双盲、安慰剂对照、随机交叉研究调查了13名健康男性受试者在不受干扰和实验干扰睡眠条件下奎替鲁对夜间尿皮质醇和褪黑激素排泄的影响。方法.志愿者连续3个晚上被研究3次（N 0，适应; N1，标准睡眠条件; N2，声应力），间隔4天。第1和2晚睡前1小时口服安慰剂、奎替鲁25 mg或奎替鲁100 mg。在8小时就寝期间产生的尿液收集后测定皮质醇和褪黑激素浓度的标准放射免疫测定。结果MANOVA显示N1与N2相比具有显著影响，皮质醇总量升高（p
Rationale. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is a frequent finding in psychiatric disorders, including psychotic depression and schizophrenia. Conflicting results exist concerning the influence of antipsychotics on the HPA-axis. Objective. Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the effect of quetiapine on nocturnal urinary cortisol and melatonin excretion in 13 healthy male subjects under conditions of undisturbed and experimentally disturbed sleep. Methods. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Placebo, quetiapine 25 mg or quetiapine 100 mg was administered orally 1 h before bedtime on nights 1 and 2. Urine produced during the 8-h bedtime period was collected for later determination of cortisol and melatonin concentrations by standard radioimmunoassays. Results. MANOVA showed a significant effect for N1 vs. N2 with elevated total amount of cortisol (p