Variety of Fruit and Vegetables and Alcohol Intake are Associated with Gut Microbial Species and Gene Abundance in Colorectal Cancer Survivors.
Variety of Fruit and Vegetables and Alcohol Intake are Associated with Gut Microbial Species and Gene Abundance in Colorectal Cancer Survivors.
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多种果实，蔬菜和酒精摄入量与结直肠癌幸存者中的肠道微生物物种以及基因丰度有关。
DOI：
10.1016/j.ajcnut.2023.07.011
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发表时间：
2023-09
期刊：
影响因子：
--
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中科院分区：
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遵守美国癌症协会（ACS）的指南，避免肥胖，保持体力活动，食用富含水果，蔬菜和全谷物的饮食与结直肠癌（CRC）幸存者的生存期延长有关。ACS指南的饮食成分可能部分通过改变微生物组起作用，这与CRC结果有关。我们进行了一项试点横断面研究，以探索ACS指南与肠道微生物组之间的关联。从2019年至2020年收集了加州大学旧金山弗朗西斯科28名CRC幸存者的粪便样本和问卷。ACS评分基于经验证的问卷计算。使用ANOVA和一般线性模型测试来自16 S扩增子的肠道微生物群落结构和来自宏基因组学的基因/途径丰度与ACS评分及其组分的关联。总体ACS评分与粪便微生物群的变化无关。然而，水果和蔬菜摄入量和酒精摄入量分别占微生物群变化的19%（P = 0.005）和13%（P = 0.01）。水果/蔬菜消费与微生物多样性增加，厚壁菌门增加，拟杆菌门减少以及多个基因和代谢途径的变化有关，包括氨基酸和短链脂肪酸生物合成和植物相关糖降解的丰富途径。相比之下，酒精消费与总体微生物多样性呈正相关，与拟杆菌属丰度呈负相关，并与多个基因和代谢途径的变化相关。ACS评分的其他组成部分与我们样本中的粪便微生物群没有统计学显著相关性。这些结果指导了未来的研究，研究水果，蔬菜和酒精饮料摄入量的变化对CRC幸存者肠道微生物组的影响。
Adherence to the American Cancer Society (ACS) guidelines of avoiding obesity, maintaining physical activity, and consuming a diet rich in fruits, vegetables, and whole grains is associated with longer survival in colorectal cancer (CRC) survivors. Dietary components of the ACS guidelines may act in part by changing the microbiome, which is implicated in CRC outcomes. We conducted a pilot cross-sectional study to explore associations between ACS guidelines and the gut microbiome. Stool samples and questionnaires were collected from 28 CRC survivors at the University of California, San Francisco from 2019 to 2020. ACS scores were calculated based on validated questionnaires. Gut microbial community structure from 16S amplicons and gene/pathway abundances from metagenomics were tested for associations with the ACS score and its components using ANOVA and general linear models. The overall ACS score was not significantly associated with variations in the fecal microbiota. However, fruit and vegetable intake and alcohol intake accounted for 19% (P = 0.005) and 13% (P = 0.01) of variation in the microbiota, respectively. Fruit/vegetable consumption was associated with increased microbial diversity, increased Firmicutes, decreased Bacteroidota, and changes to multiple genes and metabolic pathways, including enriched pathways for amino acid and short-chain fatty acid biosynthesis and plant-associated sugar degradation. In contrast, alcohol consumption was positively associated with overall microbial diversity, negatively associated with Bacteroidota abundance, and associated with changes to multiple genes and metabolic pathways. The other components of the ACS score were not statistically significantly associated with the fecal microbiota in our sample. These results guide future studies examining the impact of changes in the intake of fruits, vegetables, and alcoholic drinks on the gut microbiome of CRC survivors.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
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影响因子：
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通讯作者：
Bork, Peer
DOI：
10.1126/science.aah3648
发表时间：
2018-02-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dejea CM;Fathi P;Craig JM;Boleij A;Taddese R;Geis AL;Wu X;DeStefano Shields CE;Hechenbleikner EM;Huso DL;Anders RA;Giardiello FM;Wick EC;Wang H;Wu S;Pardoll DM;Housseau F;Sears CL
通讯作者：
Sears CL