Effects of treatment for depression on fatigue in multiple sclerosis
Effects of treatment for depression on fatigue in multiple sclerosis
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DOI：
10.1097/01.psy.0000074757.11682.96
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发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Goldberg, A
中科院分区：
文献类型：
--
作者：
Mohr, DC;Hart, SL;Goldberg, A
目的：长期以来，人们一直认为抑郁会导致多发性硬化症 (MS) 患者的疲劳。支持数据充其量是最少的。治疗疲劳的临床指南包括在缺乏明确经验支持的情况下治疗抑郁症的建议。本研究的目的是探讨抑郁症治疗对多发性硬化症患者疲劳的影响。方法：60 名患有复发型多发性硬化症和中度至重度抑郁症的患者被随机分配接受三种经过验证的 16 周抑郁症治疗方法之一：个体认知行为疗法、团体心理治疗或舍曲林。基线和停止治疗的评估包括主要结果指标、疲劳评估工具（FAI）和贝克抑郁量表（BDI）。结果：在治疗过程中，总 FAI 和整体疲劳严重程度分量表显着降低（p 值
Objective: There has long been a belief that depression contributes to fatigue in multiple sclerosis (MS) although. supporting data are minimal at best. Clinical guidelines for the treatment of fatigue include recommendations for the treatment of depression in the absence of clear empirical support. The goal of this study was to examine the effects of treatment for depression on fatigue in MS. Methods: Sixty patients with a relapsing form of MS and moderate to severe depression were randomly assigned to one of three validated 16-week treatments for depression: individual cognitive behavioral therapy, group psychotherapy, or sertraline. Assessments at baseline and treatment cessation included the primary outcome measure, fatigue assessment instrument (FAI), and Beck depression inventory (BDI). Results: The total FAI and the global fatigue severity subscale were significantly reduced over the course of treatment (p values