Hormonal determinants of the development of masculine and feminine behavior in male and female rats
Hormonal determinants of the development of masculine and feminine behavior in male and female rats
复制标题
雄性和雌性大鼠男性和女性行为发展的激素决定因素
DOI：
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发表时间：
1967
期刊：
影响因子：
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通讯作者：
D. A. Edwards
中科院分区：
文献类型：
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作者：
R. E. Whalen;D. A. Edwards
为了研究产后性腺激素对男性和女性行为发展的作用，129 只雄性和雌性大鼠在出生时接受了激素控制。在出生24小时内，雄性和雌性大鼠被：(a)假手术，(b)去性腺切除，(c)去性腺切除并给予睾酮，或(d)去性腺切除并给予雌激素。当成年后，所有动物都被给予睾酮并测试雄性行为的表现，然后给予雌激素和黄体酮并测试雌性行为。男性行为：无论出生时的激素控制如何，男性比女性更频繁地表现出越来越多的反应。出生时的雄激素和雌激素不会促进任何性别的行为增加。男性比女性表现出更频繁的插入反应。出生时接受雄激素治疗的动物比未接受治疗的动物表现出更频繁的性交行为。与女性相比，雄激素更能促进男性的性交。出生时的雌激素不会促进性交行为。女性行为：出生时阉割的男性、正常女性和出生时切除卵巢的女性表现出高水平的接受性。没有其他动物表现出频繁的脊柱前凸。数据表明，婴儿期激素诱导的行为性别分化的最佳特征是抑制表现出女性行为的潜力。
To investigate the role of gonadal hormones during the postnatal period on the development of masculine and feminine behavior 129 male and female rats were hormonally manipulated at birth. Within 24 hours of birth male and female rats were: (a) sham operated, (b) gonadectomized, (c) gonadectomized and given testosterone, or (d) gonadectomized and given estrogen. When adult all animals were given testosterone and tested for the display of male behavior, and then given estrogen and progesterone and tested for female behavior. Male behavior: Males exhibited mounting responses more frequently than females regardless of hormone manipulation at birth. Androgen and estrogen at birth did not facilitate mounting behavior in either sex. Males exhibited more frequent intromission responses than females. Animals treated with androgen at birth showed more frequent intromission behavior than non‐treated animals. Androgen facilitated intromission relatively more in males than in females. Estrogen at birth did not facilitate intromission behavior. Female behavior: Males castrated at birth, normal females, and females ovariectomized at birth showed high levels of receptivity. No other animal exhibited frequent lordosis. The data indicated that behavioral sexual differentiation induced by hormones in in‐fancy is best characterized by an inhibition of the potential to display feminine behavior.