Effects of acute hypoventilation and hyperventilation on exhaled carbon monoxide measurement in healthy volunteers.
Effects of acute hypoventilation and hyperventilation on exhaled carbon monoxide measurement in healthy volunteers.
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DOI：
10.1186/1471-2466-9-51
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发表时间：
2009-12-23
影响因子：
3.1
通讯作者：
Moscato U
中科院分区：
文献类型：
--
作者：
Cavaliere F;Volpe C;Gargaruti R;Poscia A;Di Donato M;Grieco G;Moscato U
高水平的呼出一氧化碳（eCO）是气道或肺部炎症的标志。我们调查了换气不足或换气过度是否会影响测量值。10名健康志愿者接受培训，以达到持续的潮气末CO2（etCO 2）浓度为30（过度通气），40（正常通气）和50 mmHg（通气不足）。一旦达到目标etCO 2值120秒，就用光声光谱仪分析呼出气的eCO。在etCO 2值为30和40 mmHg时，在深吸气和正常吸气后对呼出气进行采样。所有测量均在两种不同的环境条件下进行：A）环境CO浓度= 0.8 ppm和B）环境CO浓度= 1.7 ppm。正常通气时，eCO平均值（标准差）为11.5（0.8）ppm;过度通气时降至10.3（0.8）ppm（p < 0.01），通气不足时增至11.9（0.8）ppm（p < 0.01）。eCO变化不如相应的etCO 2变化明显（换气过度：10% Vs 25%降低;换气不足3% Vs 25%增加）。在呼吸采样前进行深吸气与较低的eCO值相关（p < 0.01），而环境CO水平不影响eCO测量。在明显的急性过度通气（如本研究中诱导的）期间不应进行eCO测量，但在临床实践中，不太明显的过度通气或通气不足的影响可能可以忽略不计
High levels of exhaled carbon monoxide (eCO) are a marker of airway or lung inflammation. We investigated whether hypo- or hyperventilation can affect measured values. Ten healthy volunteers were trained to achieve sustained end-tidal CO2 (etCO2) concentrations of 30 (hyperventilation), 40 (normoventilation), and 50 mmHg (hypoventilation). As soon as target etCO2 values were achieved for 120 sec, exhaled breath was analyzed for eCO with a photoacoustic spectrometer. At etCO2 values of 30 and 40 mmHg exhaled breath was sampled both after a deep inspiration and after a normal one. All measurements were performed in two different environmental conditions: A) ambient CO concentration = 0.8 ppm and B) ambient CO concentration = 1.7 ppm. During normoventilation, eCO mean (standard deviation) was 11.5 (0.8) ppm; it decreased to 10.3 (0.8) ppm during hyperventilation (p < 0.01) and increased to 11.9 (0.8) ppm during hypoventilation (p < 0.01). eCO changes were less pronounced than the correspondent etCO2 changes (hyperventilation: 10% Vs 25% decrease; hypoventilation 3% Vs 25% increase). Taking a deep inspiration before breath sampling was associated with lower eCO values (p < 0.01), while environmental CO levels did not affect eCO measurement. eCO measurements should not be performed during marked acute hyperventilation, like that induced in this study, but the influence of less pronounced hyperventilation or of hypoventilation is probably negligible in clinical practice