Resting-state network connectivity in cognitively unimpaired drug-naive patients with rigidity-dominant Parkinson's disease
Resting-state network connectivity in cognitively unimpaired drug-naive patients with rigidity-dominant Parkinson's disease
复制标题
认知未受损、未接受过药物治疗的强直性帕金森病患者的静息态网络连接
DOI：
10.1016/j.jns.2018.10.003
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发表时间：
2018-12-15
影响因子：
4.4
通讯作者：
Shang, Huifang
中科院分区：
文献类型：
--
作者：
Hou, Yanbing;Yang, Jing;Shang, Huifang
背景：帕金森病（Parkinson 'sdisease，PD）可分为运动不能强直（akinetic-rigidity，PDAR）、震颤显性（tremor-dominant，PDTD）和混合型。PDAR患者更容易出现认知缺陷。默认模式网络（DMN）、额顶叶网络（FPN）和背侧注意网络（DAN）在认知加工中起着重要作用。我们的目的是评估的DMN的连接模式的变化，其相互关系与认知未受损药物初治PDAR patients.Method：静息状态功能磁共振成像（rs-fMRI）数据收集在20个认知未受损早期药物初治PDAR患者和20个年龄，性别和认知匹配的健康对照（HC）。采用组水平独立成分分析（伊卡）研究PDAR组和HC组DMN内功能连接（FC）的变化，并通过基于种子的方法评价DMN与FPN/DAN之间的关系。左侧IPL与左侧前扣带皮层（ACC）、左侧上级额回（SFG）和左侧楔前叶的FC降低。然而，在左侧IPL和FPN/DAN之间的FC中未检测到差异。此外，认知分数的简短视觉空间记忆测试修订（BVMT-R），代表认知记忆域，与FC的左侧IPL与双边SFG.Conclusions：我们的研究主要揭示了改变内DMN连接在认知未受损的PDAR患者，这可以提供进一步的洞察PD亚型的认知功能下降演变的机制。
Background: Parkinson's disease (PD) could be classified into akinetic-rigidity (PDAR), tremor-dominant (PDTD) and mixed subtypes. PDAR patients are more prone to develop cognitive deficits. The default mode network (DMN), fronto-parietal network (FPN) and dorsal attention network (DAN) play important roles in cognitive processing. Our aim was to evaluate changes in connectivity patterns of the DMN, and its interrelation with the FPN and DAN in cognitively unimpaired drug-naive PDAR patients.Method: Resting-state functional MRI (rs-fMRI) data was collected in 20 cognitively unimpaired early-stage drug-naive PDAR patients and 20 age-, gender- and cognition- matched healthy controls (HCs). Group-level independent component analysis (ICA) was used to investigate changes in functional connectivity (FC) within the DMN between PDAR and HCs groups, and relationships between the DMN and FPN/DAN were evaluated by seed-based approach.Results: In PDAR patients, a significantly decreased FC, as compared with HCs, was observed in the left inferior parietal lobule (IPL) within the DMN. And the left IPL had a reduced FC with the left anterior cingulate cortex (ACC), left superior frontal gyrus (SFG), and left precuneus. However, no differences were detected in the FC between the left IPL and FPN/DAN. In addition, cognitive scores on the brief visuospatial memory test revised (BVMT-R), representing for cognitive memory domain, were positively correlated with the FC of the left IPL with bilateral SFG.Conclusions: Our study mainly revealed altered within-DMN connectivity in cognitively unimpaired PDAR patients, which could provide further insights into the mechanism underlying cognitive decline evolution in the PD subtype.