UNIT-ACTIVITY IN PREFRONTAL CORTEX DURING DELAYED-RESPONSE PERFORMANCE - NEURONAL CORRELATES OF TRANSIENT MEMORY
UNIT-ACTIVITY IN PREFRONTAL CORTEX DURING DELAYED-RESPONSE PERFORMANCE - NEURONAL CORRELATES OF TRANSIENT MEMORY
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DOI：
10.1152/jn.1973.36.1.61
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发表时间：
1973-01-01
影响因子：
2.5
通讯作者：
FUSTER, JM
中科院分区：
文献类型：
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作者：
FUSTER, JM
自从雅各布森（Jacobsen，22，23）对灵长类动物进行了最初的研究以来，人们一直认为额叶的颗粒皮质（也称为前额叶皮质）在短期记忆中发挥作用。这是一个推论，从赤字的损害，这一皮层区域造成的表现上的延迟反应测试。延迟响应。LLV由TL试验（典型的LC呈现线索的两种可能的视觉动作之一）、XI随后的时间段IT、一组强制延迟和在与该线索一致的N雅阁时的运动反应I的声音组成。提示和反应之间的时间分离是使延迟反应程序成为对操作上定义的短期记忆功能的测试的主要因素。然而，作为参与短时记忆的心理过程，延迟反应操作所涉及的神经过程可能是多而复杂的。前额叶皮层在其中的确切作用尚不清楚，与额叶消融效应的大量文献相反，延迟反应行为的神经电相关性的文献是简短而新近的。1969年，Stamm和罗森（43）在一项延迟反应测试中发现，猴子大脑皮层中的电位发生了稳定的变化。他们最重要的发现是，在延迟期开始时，额叶皮层表面出现缓慢的负电位，这表明该区域的神经元兴奋性增加。Kubota和Niki（27）最近报道了单位的射击变化，
SINCE THE ORIGINAL investigations of Jacobsen (22, 23) in primates, the granular cortex of the frontal lobe, also called prehontal cortex, has been thought to play a role in short-term memory. This is an inference from the deficits that lesions of this cortical region cause on performance of delayed-response tests. A delayed-response. llv consists of tl trial typica one of two possible visual tation of lc presen cues, xi ensuing period it, a ch of enforced delay and, oice of motor response i at the end n accord wi of th the cue. The temporal separation between cue and response is the principal element making the delayed-response procedure a test of an operationally defined short-term memory function. However, the neural processes i nvolvetl in delayed-response performance, as the psychological processes participating in short-term memory, are probably many and complex. The precise role of the prefrontal cortex in these is not yet clear.In contrast to the abundant documen tation of the effects of frontal ablations, the literature 011 the neuroelectrical correlates of delayed-response behavior is brief and recent. In 1969, Stamm and Rosen (43) showed steady potential shifts in the cortex of monkeys during a delayed-response test. Their most significant finding was a slow negative potential on the surface of the l&frontal cortex at the beginning of the delay period, suggesting that at that time there is in that region an increase of neuronal excitability. Kubota and Niki (27) have more recently reported firing changes of units irl t 1~ periprincipal area of the