Highly Chemoselective Construction of Spiro[4,5]decane-Embedded Polycyclic Scaffolds by a Palladium/Norbornene-Catalyzed C-H Activation/Arene Dearomatization Reaction.
Highly Chemoselective Construction of Spiro[4,5]decane-Embedded Polycyclic Scaffolds by a Palladium/Norbornene-Catalyzed C-H Activation/Arene Dearomatization Reaction.
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DOI：
10.1021/acs.orglett.8b03518
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发表时间：
2018-11
期刊：
影响因子：
5.2
通讯作者：
Jiang Nan;Yini Yuan;Lu Bai;Jingjing Liu;X. Luan
中科院分区：
文献类型：
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作者：
Jiang Nan;Yini Yuan;Lu Bai;Jingjing Liu;X. Luan
在钯/降冰片烯催化下，成功地建立了苯酚基双芳基与溴烷基炔的高化学选择性分子间环化反应。这一多米诺骨牌过程是通过catellani型C-H功能化、炔迁移插入和芳烃去芳化的级联反应完成的，从而产生了大量含有各种官能团的螺[4,5]嵌入癸烷的多环分子，收率中等至优异。
A highly chemoselective intermolecular annulation reaction of phenol-based biaryls with bromoalkyl alkynes has been successfully developed by palladium/norbornene catalysis. This domino process was accomplished by following a cascade of Catellani-type C-H functionalization, alkyne migratory insertion, and arene dearomatization, thus leading to a large number of spiro[4,5]decane-embedded polycyclic molecules bearing various functional groups in moderate to excellent yields.