Investigating the human spinal sensorimotor pathways through functional magnetic resonance imaging.
Investigating the human spinal sensorimotor pathways through functional magnetic resonance imaging.
复制标题
通过功能性磁共振成像研究人体脊髓感觉运动通路。
DOI：
10.1016/j.neuroimage.2021.118684
复制
发表时间：
2021-12-15
期刊：
影响因子：
5.7
通讯作者：
Doyon, Julien
中科院分区：
文献类型：
--
作者：
Landelle, Caroline;Lungu, Ovidiu;Doyon, Julien
我们对人类脊椎上升(感觉)和下降(运动)通路的大部分知识来自于非侵入性的电生理研究。然而，最近在获取和分析脊髓功能磁共振成像(FMRI)数据方面的方法学进步，无论是单独还是与大脑结合，都使我们能够进一步了解这一结构的组织。在目前的综述中，我们进行了一项系统的研究，以产生通过不同的躯体感觉、运动和静息状态范式观察到的脊髓fMRI活动的体视图。通过将这些人类神经成像结果与通过神经生理记录获得的知识进行交叉参考，我们的综述表明，脊髓功能磁共振成像是在活体内探索人类脊髓通路的强大工具。我们报告了与任务相关的和静息状态的fMRI之间强烈的交叉验证，根据这些通路的已知的半轴、后前部和吻尾部的组织。我们还强调了在临床环境中使用脊柱功能磁共振成像的特定优势，以更好地描述与脊柱相关的损伤，预测疾病进展，并指导治疗干预措施的实施。
Most of our knowledge about the human spinal ascending (sensory) and descending (motor) pathways comes from non-invasive electrophysiological investigations. However, recent methodological advances in acquisition and analyses of functional magnetic resonance imaging (fMRI) data from the spinal cord, either alone or in combination with the brain, have allowed us to gain further insights into the organization of this structure. In the current review, we conducted a systematic search to produced somatotopic maps of the spinal fMRI activity observed through different somatosensory, motor and resting-state paradigms. By cross-referencing these human neuroimaging findings with knowledge acquired through neurophysiological recordings, our review demonstrates that spinal fMRI is a powerful tool for exploring, in vivo, the human spinal cord pathways. We report strong cross-validation between task-related and resting-state fMRI in accordance with well-known hemicord, postero-anterior and rostro-caudal organization of these pathways. We also highlight the specific advantages of using spinal fMRI in clinical settings to characterize better spinal-related impairments, predict disease progression, and guide the implementation of therapeutic interventions.