Genetic risk for ischemic and hemorrhagic stroke
Genetic risk for ischemic and hemorrhagic stroke
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DOI：
10.1161/01.atv.0000229694.97827.38
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发表时间：
2006-08-01
影响因子：
8.7
通讯作者：
Nozawa, Yoshinori
中科院分区：
文献类型：
--
作者：
Yamada, Yoshiji;Metoki, Norifumi;Nozawa, Yoshinori
目的：我们进行了一项关联研究，以确定基因多态对缺血性或出血性中风遗传风险的评估。方法和结果-研究人群包括3151名无关的日本人：1141名中风患者(636例动脉粥样硬化性脑梗塞，282例脑出血，223例蛛网膜下腔出血)和2010名对照。采用悬浮芯片技术对152个基因的202个多态性进行了基因分型。多因素Logistic回归分析显示，IL-6基因-572G-GT；C多态与动脉粥样硬化性脑梗塞和脑出血显著相关(P<0.001)，解偶联蛋白3基因-55C-GT多态、-863C-GT多态与脑出血显著相关(P<0.05)。肿瘤坏死因子(TNF)基因和多囊肾病1类基因(PKD1样)的G-A(Gly243Asp)多态性与蛛网膜下腔出血显著相关。结论IL6基因可用于评估动脉粥样硬化性脑梗塞和脑出血的遗传风险，UCP3、肿瘤坏死因子和PKD1-Iike基因可能同样有助于蛛网膜下腔出血的风险评估。要验证我们的发现，需要用独立的主题小组进行更多的研究。
Objective-We performed an association study to identify gene polymorphisms for assessing the genetic risk of ischemic or hemorrhagic stroke.Methods and Results-The study population comprised 3151 unrelated Japanese individuals: 1141 stroke patients (636 with atherothrombotic cerebral infarction, 282 with intracerebral hemorrhage, and 223 with subarachnoid hemorrhage) and 2010 controls. The genotypes for 202 polymorphisms of 152 genes were determined by suspension array technology. Multivariable logistic regression analysis with adjustment for conventional risk factors revealed that the -572G -> C polymorphism of the interleukin-6 (IL-6) gene (IL6) was significantly (P < 0.001) associated with both atherothrombotic cerebral infarction and intracerebral hemorrhage and that the -55C -> T polymorphism of the uncoupling protein 3 gene (UCP3), the -863C -> A polymorphism of the tumor necrosis factor (TNF) gene (TNF), and the G-A (Gly243Asp) polymorphism of the polycystic kidney disease 1-like gene (PKD1-like) were significantly associated with subarachnoid hemorrhage.Conclusions-IL6 genotype may be useful in assessing the genetic risk for atherothrombotic cerebral infarction and intracerebral hemorrhage, and genotypes for UCP3, TNF, and PKD1-Iike may be similarly beneficial in assessment of the risk for subarachnoid hemorrhage. Validation of our findings will require additional studies with independent subject panels.