Relations between cognitive and symptom profile heterogeneity in schizophrenia
Relations between cognitive and symptom profile heterogeneity in schizophrenia
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DOI：
10.1097/00005053-199907000-00004
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发表时间：
1999-07-01
影响因子：
1.9
通讯作者：
van Kammen, DP
中科院分区：
文献类型：
--
作者：
Seaton, BE;Allen, DN;van Kammen, DP
尽管许多研究一致揭示了精神分裂症的认知异质性，但这种异质性与临床现象学之间的关系尚不清楚。来自认知异质性研究的聚类可能与症状特征或疾病严重程度相关，也可能无关。本研究旨在探讨认知异质性与人口统计学和临床现象学指标之间的关系。我们研究了认知异质性精神分裂症的经验得出集群的患者的基础上WAIS-R分测验分数，然后分析了这些集群相关的人口统计学和症状变量和DSM-III-R，诊断亚型的方式。确定了四个认知集群，这与以前的研究是一致的。这些聚类是根据教育水平和职业状况进行区分的，而不是根据症状特征、严重程度或DSM-III-R亚型进行区分。结果表明，认知措施是独立的严重程度的障碍和现象学症状表现在这些亚组的精神分裂症患者。
Although numerous studies have consistently revealed cognitive heterogeneity in schizophrenia, the relationships between such heterogeneity and clinical phenomenology are not clear. Clusters derived from cognitive heterogeneity studies may or may not be associated with symptom profile or severity of illness. The purpose of this study was to examine the relationship between cognitive heterogeneity and demographic and clinical phenomenological measures. We examined cognitive heterogeneity in schizophrenia by empirically deriving clusters of patients based upon WAIS-R subtest scores and then analyzed the way in which these clusters related to demographic and symptom variables and to DSM-III-R, diagnostic subtypes. Four cognitive clusters were identified that were consistent with previous research. These clusters were differentiated on the basis of educational level and occupational status but not on the basis of symptom profile, severity, or DSM-III-R subtypes. Results suggest that cognitive measures are independent of severity of the disorder and phenomenological symptom presentation in these subgroups of schizophrenic patients.