Flecainide versus quinidine: results of a multicenter trial.
Flecainide versus quinidine: results of a multicenter trial.
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氟卡尼与奎尼丁：多中心试验的结果。
DOI：
10.1016/0002-9149(84)90505-8
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
G. Granrud
中科院分区：
文献类型：
--
作者：
M. Hodges;D. Salerno;G. Granrud
在这项多中心试验中，氟卡尼，一种新的抗癫痫药的有效性和安全性进行了比较奎尼丁，一个标准的抗癫痫药在美国。采用随机、平行、安慰剂对照设计。氟卡尼在减少室性早搏、室性联搏和室性心动过速方面比奎尼丁更有效（p < 0.0001）。在12个月的随访期间，氟卡尼继续有效地减少室性心律失常。在短期和长期研究中，两种药物的副作用发生率相似。因此，氟卡尼应该是一个很好的药物用于治疗室性心律失常的患者分类为良性或潜在恶性。
In this multicenter trial, the efficacy and safety of flecainide, a new antiarrhythmic agent, were compared with those of quinidine, a standard antiarrhythmic agent in the United States. A randomized, parallel, placebo-controlled design was used. Flecainide was more effective than quinidine (p < 0.0001) in reducing ventricular premature complexes, couplets and ventricular tachycardia. Flecainide continued to be effective in reducing ventricular arrhythmias during a 12-month follow-up period. The incidence of side effects was similar for the 2 drugs in both short- and long-term studies. Therefore, flecainide should be an excellent drug to use in treating patients with ventricular arrhythmias classified as either benign or potentially malignant.
每日两次服用氟卡尼可抑制难治性室性心律失常。
DOI：
10.1016/0002-9149(81)90331-3
发表时间：
1981
期刊：
The American journal of cardiology
影响因子：
--
作者：
Duff,HJ;Roden,DM;Maffucci,RJ;Vesper,BS;Conard,GJ;Higgins,SB;Oates,JA;Smith,RF;Woosley,RL
通讯作者：
Woosley,RL