NOCICEPTIVE NEURONS IN AREA-24 OF RABBIT CINGULATE CORTEX
NOCICEPTIVE NEURONS IN AREA-24 OF RABBIT CINGULATE CORTEX
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DOI：
10.1152/jn.1992.68.5.1720
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发表时间：
1992-11-01
影响因子：
2.5
通讯作者：
VOGT, BA
中科院分区：
文献类型：
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作者：
SIKES, RW;VOGT, BA
1.在氟烷麻醉的家兔中，在用经皮电刺激（TCES，3-10 mA）、机械刺激（光滑或锯齿状镊子到背侧体表或100- 1，500 g的梯度压力到稳定的耳朵）和热刺激（>25 ℃）刺激皮肤期间，检查扣带皮层24区的单单位反应。在扣带皮层测试的542个单位中，150个对有害的TCES（大于或等于6 mA）有反应，221个单位中的93个对有害的机械（锯齿钳）有反应，47个单位中的9个对有害的热（>43 ℃）刺激有反应。25%的对有害机械刺激有反应的单位也对有害热刺激有反应。引起扣带皮层活动的唯一无害刺激是对皮肤的“轻拍”，这对14个测试单位中的11个有效。在对侧耳TCES产生兴奋性反应的74个单位中，反应潜伏期为166 +/- 11.3（SE）ms，反应持续时间为519 +/- 52.1 ms。150个对有毒TCES有反应的单位中有20个最初受到抑制。这些反应通常是
1. Single-unit responses in area 24 of cingulate cortex were examined in halothane-anesthetized rabbits during stimulation of the skin with transcutaneous electrical (TCES, 3-10 mA), mechanical (smooth or serrated forceps to the dorsal body surface or graded pressures of 100-1,500 g to the stabilized ear) and thermal (>25-degrees-C) stimulation.2. Of 542 units tested in cingulate cortex, 150 responded to noxious TCES (greater-than-or-equal-to 6 mA), 93 of 221 units tested responded to noxious mechanical (serrated forceps) and 9 of 47 units tested responded to noxious heat (>43-degrees-C) stimuli. Twenty-five percent of the units that responded to noxious mechanical stimuli also responded to noxious heat stimuli. The only innocuous stimulus that evoked activity in cingulate cortex was a "tap" to the skin and this was effective for 11 of 14 tested units.3. In 74 units that produced excitatory responses to TCES of the contralateral ear, response latency was 166 +/- 11.3 (SE) ms and response duration was 519 +/- 52.1 ms.4. Twenty of the 150 units that responded to noxious TCES were initially inhibited. These responses were usually