Highly Emissive Self-Assembled BODIPY-Platinum Supramolecular Triangles.
Highly Emissive Self-Assembled BODIPY-Platinum Supramolecular Triangles.
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DOI：
10.1021/jacs.8b04929
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发表时间：
2018-05
影响因子：
15
通讯作者：
Jiong Zhou;Yuzhen Zhang;Guocan Yu;Matthew R. Crawley;C. R. P. Fulong;A. Friedman;S. Sengupta;
中科院分区：
文献类型：
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作者：
Jiong Zhou;Yuzhen Zhang;Guocan Yu;Matthew R. Crawley;C. R. P. Fulong;A. Friedman;S. Sengupta;
发光超分子配合物在化学和生物科学中有着广泛的应用。在此，我们报告了两个高发射铂（II）超分子三角形（1和2）含有BODIPY为基础的桥接配体的配位驱动的自组装。金属杂环化合物对HeLa细胞具有良好的抗癌活性（IC 50分别为6.41和2.11 μ M）。特征性的570 nm荧光的硼二吡咯亚甲基（BODIPY）部分的金属杂环允许其细胞内可视化使用共聚焦显微镜。此外，BODIPY荧光团是一种出色的光动力剂，使金属杂环化合物成为光动力疗法（PDT）和化疗的理想治疗剂。体外研究表明，1和2对HeLa细胞的联合指数分别为0.56和0.48，证实了它们的协同抗癌作用。更重要的是，这些SCC还表现出对顺铂耐药的A2780 cis细胞系的上级抗癌效果，通过结合PDT和化疗，显示出克服耐药性的前景。本研究利用了自组装金属笼的多组分方法，该方法能够设计有效的治疗诊断剂，其中铂受体是毒性化疗剂，BODIPY供体是成像探针和光敏剂。由于每个片段可以被独立地调谐，即，Pt（II）多吡啶基片段交换为Pt（II）膦，可以优化活性而无需系统的完全重新设计。
Light-emitting supramolecular coordination complexes (SCCs) have been widely studied for applications in the chemical and biological sciences. Herein, we report the coordination-driven self-assembly of two highly emissive platinum(II) supramolecular triangles (1 and 2) containing BODIPY-based bridging ligands. The metallacycles exhibit favorable anticancer activities against HeLa cells (IC50 of 6.41 and 2.11 μM). The characteristic ∼570 nm fluorescence of the boron dipyrromethene (BODIPY) moieties in the metallacycles permits their intracellular visualization using confocal microscopy. Additionally, the BODIPY fluorophore is an excellent photodynamic agent, making the metallacycles as ideal therapeutics for photodynamic therapy (PDT) and chemotherapy. In vitro studies demonstrate that the combination indexes against HeLa cells are 0.56 and 0.48 for 1 and 2, respectively, confirming their synergistic anticancer effect. More importantly, these SCCs also exhibit superior anticancer efficacy toward cisplatin-resistant A2780cis cell line by combining PDT and chemotherapy, showing promise in overcoming drug resistance. This study exploits a multicomponent approach to self-assembled metallacages that enables design of effective theranostic agents wherein the platinum acceptors are toxic chemotherapeutics and the BODIPY donors are imaging probes and photosensitizers. Since each piece may be independently tuned, i.e., Pt(II) polypyridyl fragment swapped for Pt(II) phosphine, the activity may be optimized without a total redesign of the system.