Studies on diffusion in alginate gels .1. Effect of cross-linking with calcium or zinc ions on diffusion of acetaminophen
Studies on diffusion in alginate gels .1. Effect of cross-linking with calcium or zinc ions on diffusion of acetaminophen
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DOI：
10.1016/0168-3659(96)01369-7
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发表时间：
1996-10-01
影响因子：
10.8
通讯作者：
Kennedy, RA
中科院分区：
文献类型：
--
作者：
Aslani, P;Kennedy, RA
使用并列式玻璃扩散池测量了对乙酰氨基酚在水合海藻酸盐和海藻酸凝胶中的渗透性。通过在乙酸钙或乙酸锌水溶液（0.1至0.7 M）中于25℃下将海藻酸钠薄膜交联1至30分钟来制备凝胶薄膜。在0.34 M阳离子溶液中制备15分钟的薄膜在扩散研究之前，要么暴露于不含胃蛋白酶的美国药典模拟胃液中，要么在45℃下干燥至恒重然后再水合。凝胶薄膜中对乙酰氨基酚的渗透性随着二价阳离子浓度和交联时间的增加而降低，直至达到明显的最佳值。渗透性降低被认为是由于凝胶结构中交联增加所致。对乙酰氨基酚在凝胶薄膜中的渗透性按海藻酸凝胶薄膜＞酸处理的海藻酸盐凝胶薄膜＞二价海藻酸盐凝胶薄膜的顺序降低。脱水降低了对乙酰氨基酚在海藻酸钙凝胶薄膜中的渗透性。总体而言，对乙酰氨基酚在海藻酸钙和海藻酸锌凝胶薄膜中的渗透性差异不大。
The permeability of acetaminophen in hydrated alginate and alginic acid gels was measured using side-by-side glass diffusion cells. Gel films were prepared by cross-linking sodium alginate films in aqueous solutions (0.1 to 0.7 M) of calcium or zinc acetate for 1 to 30 min at 25 degrees C. Films prepared in 0.34 M cation solution for 15 min were either exposed to Simulated Gastric Fluid USP minus pepsin, or dried at 45 degrees C to constant weight and then rehydrated, prior to a diffusion study. Acetaminophen permeability in the gel films decreased with increasing divalent cation concentration and cross-linking time until an apparent optimum was reached. The decreased permeability was suggested to be due to increased cross-linking in the gelled structure. The permeability of acetaminophen in the gel films decreased in the order alginic acid gel films > acid-exposed alginate gel films > divalent alginate gel films. Dehydration decreased the permeability of acetaminophen in the Ca alginate gel films. Overall, there was little difference between the permeability of acetaminophen in Ca or Zn alginate gel films.