THE ROLE OF CEA, TPA AND CA 19-9 IN THE EARLY DETECTION OF RECURRENT COLORECTAL-CANCER
THE ROLE OF CEA, TPA AND CA 19-9 IN THE EARLY DETECTION OF RECURRENT COLORECTAL-CANCER
复制标题
DOI：
10.1007/bf01644987
复制
发表时间：
1989-01-01
影响因子：
2.8
通讯作者：
FEGIZ, G
中科院分区：
文献类型：
--
作者：
BARILLARI, P;RAMACCIATO, G;FEGIZ, G
对1983 ~ 1985年间连续88例结直肠癌根治性切除患者进行前瞻性研究，以评价CEA、TPA和CA 19-9测定和独立临床检查在可切除复发早期诊断中的作用。在初次手术后8至38个月检测到29例复发。CEA、TPA和CA 19-9的敏感性分别为72%、62%和38%，特异性分别为78%、86%和97%。在CEA未升高的8例复发中，5例诱发TPA升高，2例诱发CA 19-9升高。三种标志物之一的血清浓度升高是23例（79%）患者复发的第一个迹象。两个二次剖腹探查手术的基础上上升的血清标志物进行。在一个病例中发现了弥漫性复发性疾病，在另一个病例中发现了可切除的孤立性肝转移瘤。
Eighty-eight consecutive patients who underwent curative resection for colorectal cancer between 1983 and 1985 were studied prospectively to evaluate the roles of sequential CEA, TPA and CA 19-9 determinations and independent clinical examination in the early diagnosis of resectable recurrences. Twenty nine recurrences were detected between 8 and 38 months after primary surgery. CEA, TPA and CA 19-9 showed a sensitivity of 72%, 62% and 38%, and a specificity of 78%, 86% and 97%, respectively. Of eight recurrences in which CEA was not raised, five induced a rise in TPA and two a rise in CA 19-9. The rise in the serum concentration of one of the three markers was the first sign of relapse in 23 (79%) patients. Two second-look laparotomies based soley on a rise in serum markers were performed. In one case diffuse recurrent disease was found, and in the other a resectable solitary hepatic metastasis was found.