ADRENAL-FUNCTION IN DIABETIC MUTANT MOUSE (GENE SYMBOL DBM)
ADRENAL-FUNCTION IN DIABETIC MUTANT MOUSE (GENE SYMBOL DBM)
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DOI：
10.1111/j.1748-1716.1976.tb10327.x
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
NAESER, P
中科院分区：
文献类型：
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作者：
NAESER, P
通过测定血清皮质激素、肾上腺质量和肾上腺皮质激素含量，研究了雾蒙蒙毛色糖尿病突变小鼠的肾上腺功能。研究了肥胖-高血糖小鼠（ob）的肾上腺皮质类固醇含量。dbm小鼠血清皮质类固醇水平在5月龄和12月龄时升高，尽管肾上腺重量仅在5月龄时显著升高。12月龄dbm小鼠的肾上腺皮质类固醇含量显著降低。在ob-小鼠中，肾上腺皮质类固醇含量在5周、5和12个月时升高。在dbm-小鼠和ob-小鼠中，肾上腺皮质的功能活性增加，这可能反映了垂体ACTH过度，可能是一种常见的下丘脑疾病的表现。
Adrenal function in diabetes mutant mice with misty coat color (dbm) was investigated by measurements of serum corticosteroids, adrenal weights and adrenal corticosteroid content. The adrenal corticosteroid content was studied in obese-hyperglycemic mice (ob). In dbm-mice serum corticosteroid levels were elevated at the age of 5 and 12 mo., although adrenal weight was only significantly elevated at the age of 5 mo. Adrenal corticosteroid content was significantly lower in the 12 mo. old dbm-mice. In ob-mice the adrenal corticosteroid content was elevated at the age of 5 wk, 5 and 12 mo. In the dbm-mouse and the ob-mouse there is an increased functional activity of the adrenal cortex which may reflect a pituitary hypersection of ACTH, perhaps as a manifestation of a common hypothalamic disorder.