Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice.
Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice.
复制标题
Riluzole 可挽救 rTg4510 小鼠海马中快速谷氨酸瞬变的改变。
DOI：
10.1007/s11011-015-9783-9
复制
发表时间：
2016
影响因子：
3.6
通讯作者：
Reed,MirandaN
中科院分区：
文献类型：
--
作者：
Hunsberger,HollyC;Hickman,JamesE;Reed,MirandaN
Those at risk for Alzheimer’s disease (AD) often exhibit hippocampal hyperexcitability in the years preceding diagnosis. Our previous work with the rTg(TauP301L)4510 tau mouse model of AD suggests that this increase in hyperexcitability is likely mediated by an increase in depolarization-evoked glutamate release and a decrease in glutamate uptake, alterations of which correlate with learning and memory deficits. Treatment with riluzole restored glutamate regulation and rescued memory deficits in the TauP301L model. Here, we used enzyme-based ceramic microelectrode array technology to measure real-time phasic glutamate release and uptake events in the hippocampal subregions of TauP301L mice. For the first time, we demonstrate that perturbations in glutamate transients (rapid, spontaneous bursts of glutamate) exist in a tau mouse model of AD mouse model and that riluzole mitigates these alterations. These results help to inform our understanding of how glutamate signaling is altered in the disease process and also suggest that riluzole may serve as a clinically applicable therapeutic approach in AD.
